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Comment
. 2017 Jan;33(1):1-2.
doi: 10.1016/j.tig.2016.11.005. Epub 2016 Nov 28.

Darwin Comes to Clinic

Arthur L Beaudet  1
Affiliations
Comment

Darwin Comes to Clinic

Arthur L Beaudet. Trends Genet. 2017 Jan.

Abstract

What might be the benefits of whole-genome rather than whole-exome sequencing (WES) for identifying the genetic causes of human disabilities? A recent paper by Doan et al. focuses attention on mutations in human accelerated regions (HARs), a subset of genomic regulatory elements showing accelerated evolution between chimpanzees and humans.

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  • Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior.
    Doan RN, Bae BI, Cubelos B, Chang C, Hossain AA, Al-Saad S, Mukaddes NM, Oner O, Al-Saffar M, Balkhy S, Gascon GG; Homozygosity Mapping Consortium for Autism; Nieto M, Walsh CA. Doan RN, et al. Cell. 2016 Oct 6;167(2):341-354.e12. doi: 10.1016/j.cell.2016.08.071. Epub 2016 Sep 22. Cell. 2016. PMID: 27667684 Free PMC article.

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