Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug 31;9(2):1413.
doi: 10.4022/jafib.1413. eCollection 2016 Aug-Sep.

Brugada Syndrome:Risk Stratification And Management

Konstantinos P Letsas  1 , Stamatis Georgopoulos  1 , Konstantinos Vlachos  1 , Nikolaos Karamichalakis  1 , Ioannis Liatakis  1 , Panagiotis Korantzopoulos  2 , Tong Liu  3 , Michael Efremidis  1 , Antonios Sideris  1
Affiliations
Review

Brugada Syndrome:Risk Stratification And Management

Konstantinos P Letsas et al. J Atr Fibrillation. .

Abstract

The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification. Among these ECG markers, QRS-fragmentation appears very promising. Although the value of electrophysiological study still remains controversial, it appears to add important information on risk stratification, particularly when incorporated in multiparametric scores in combination with other known risk factors. The present review article provides an update on the pathophysiology, risk stratification and management of patients with BrS.

Keywords: Brugada syndrome; electrophysiological study; risk stratification; sudden cardiac death.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:. Clinical, electrocardiographic and electrophysiological markers proposed for risk stratification in BrS
See this image and copyright information in PMC

References

    1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J. Am. Coll. Cardiol. 1992 Nov 15;20 (6):1391–6. - PubMed
    1. Martini B, Nava A, Thiene G, Buja G F, Canciani B, Scognamiglio R, Daliento L, Dalla Volta S. Ventricular fibrillation without apparent heart disease: description of six cases. Am. Heart J. 1989 Dec;118 (6):1203–9. - PubMed
    1. Antzelevitch Charles, Brugada Pedro, Borggrefe Martin, Brugada Josep, Brugada Ramon, Corrado Domenico, Gussak Ihor, LeMarec Herve, Nademanee Koonlawee, Perez Riera Andres Ricardo, Shimizu Wataru, Schulze-Bahr Eric, Tan Hanno, Wilde Arthur. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005 Feb 8;111 (5):659–70. - PubMed
    1. Antzelevitch Charles, Patocskai Bence. Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects. Curr Probl Cardiol. 2016 Jan;41 (1):7–57. - PMC - PubMed
    1. Mizusawa Yuka, Wilde Arthur A M. Brugada syndrome. Circ Arrhythm Electrophysiol. 2012 Jun 1;5 (3):606–16. - PubMed