Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017:1521:195-204.
doi: 10.1007/978-1-4939-6588-5_13.

Gene Transfer to Rodent Hearts In Vivo

Federica Del Monte  1 , Kiyotake Ishikawa  2 , Roger J Hajjar  3
Affiliations

Gene Transfer to Rodent Hearts In Vivo

Federica Del Monte et al. Methods Mol Biol. 2017.

Abstract

Altering expression of specific genes in rodent models allows the dissection of various pathways involved in various disease states. Advances in gene transfer technologies produced vectors with tissue specificity, various time courses, increasing or knocking down genes in an externally controlled fashion. To achieve this goal, appropriate vector delivery method is essential for successfully conducting experiments. In this chapter, we focus on cardiac gene transfer in rodents that can be employed for delivering both viral and nonviral vectors.

Keywords: Adeno virus; Adeno-associated virus; Gene delivery; Modified RNA; Mouse; Plasmid; Rat; Small animals.

PubMed Disclaimer

Publication types

LinkOut - more resources