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Review
. 2016 Oct 15;44(5):1305-1312.
doi: 10.1042/BST20160146.

Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3

Teresa Rubio  1 , Maja Köhn  1
Affiliations
Review

Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3

Teresa Rubio et al. Biochem Soc Trans. .

Abstract

The phosphatase of regenerating liver (PRL)-3 is overexpressed in many human cancer types and tumor metastases when compared with healthy tissues. Different pathways and mechanisms have been suggested to modulate PRL-3 expression levels and activity, giving some valuable insights but still leaving an incomplete picture. Investigating these mechanisms could provide new targets for therapeutic drug development. Here, we present an updated overview and summarize recent findings concerning the different PRL-3 expression regulatory mechanisms and posttranslational modifications suggested to modulate the activity, localization, or stability of this phosphatase.

Keywords: PTP4A3; cancer; dual-specificity phosphatases; metastasis; post-translational modification; protein phosphatases.

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Figures

Figure 1.
Figure 1.. Schematic representation of the posttranslational modifications described or predicted for PRL-3.
Figure 2.
Figure 2.. Representation of the different regulators of PRL-3 at transcriptional, translational, and posttranslational levels.
See this image and copyright information in PMC

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