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Comment
. 2016 Dec 1;19(6):677-678.
doi: 10.1016/j.stem.2016.11.012.

The Mediator of Hematopoietic Stem Cell Homeostasis

Sneha Borikar  1 , Jennifer J Trowbridge  2
Affiliations
Comment

The Mediator of Hematopoietic Stem Cell Homeostasis

Sneha Borikar et al. Cell Stem Cell. .

Abstract

Mechanisms establishing and maintaining promoter-enhancer interactions in hematopoietic stem cells (HSCs) to maintain stem cell identity are not fully understood. In this issue of Cell Stem Cell, Aranda-Orgilles et al. (2016) describe a role for a member of the Mediator complex in maintaining HSC-specific enhancers and hematopoietic homeostasis.

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Figures

Figure 1.
Figure 1.. Function of Med12 in Regulation of Key HSC Enhancers
Aranda-Orgilles et al. propose that the Mediator complex member Med12 functions in enhancer regulation and survival of hematopoietic stem cells (HSCs). The loss of Med12 in HSCs (right panel) leads to loss of p300 binding, PolII, and H3K27ac at enhancer and super-enhancer regions that control key HSC genes. This leads to downregulation of gene expression and induction of HSC apoptosis, causing rapid bone marrow failure.
See this image and copyright information in PMC

Comment on

  • MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
    Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I. Aranda-Orgilles B, et al. Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25. Cell Stem Cell. 2016. PMID: 27570068 Free PMC article.

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