Enhancing Stem Cell Transplantation with "Nutri-technology"
- PMID: 27912088
- PMCID: PMC7474735
- DOI: 10.1016/j.stem.2016.11.015
Enhancing Stem Cell Transplantation with "Nutri-technology"
Abstract
It is necessary to employ myeloablative irradiation or chemotherapy to deplete the HSC niche to optimize hematopoietic stem cell transplantation. In a recent issue of Science, Taya and colleagues provide evidence for an alternative to the toxic chemoirradiative procedure by showing that a valine-restricted diet is sufficient to empty the bone marrow niche.
Copyright © 2016. Published by Elsevier Inc.
Comment on
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Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.Science. 2016 Dec 2;354(6316):1152-1155. doi: 10.1126/science.aag3145. Epub 2016 Oct 20. Science. 2016. PMID: 27934766
References
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- Kornberg A (1946). J Biol. Chem 164, 203–212. - PubMed
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