Clinical Evaluation and Management of Radiation Fibrosis Syndrome

Abstract

Radiation fibrosis syndrome describes the multiple neuromuscular, musculoskeletal, visceral, and other late effects that result from radiation-induced fibrosis. Radiation can damage the spinal cord, nerve roots, plexus, local peripheral nerves, and muscles within the radiation field. This constellation is known as a "myelo-radiculo-plexo-neuro-myopathy" and can result in pain, sensory loss, weakness, and other signs and symptoms. Although there is no curative treatment for radiation damage, supportive management of symptoms can be helpful in restoring and maintaining function and quality of life.

Keywords: Cancer; Head and neck cancer; Hodgkin lymphoma; Late effects; Musculoskeletal; Neuromuscular; Radiation fibrosis syndrome; Rehabilitation.