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Review
. 2016 Dec 2;2016(1):38-42.
doi: 10.1182/asheducation-2016.1.38.

Autoimmune and other acquired neutropenias

Peter E Newburger  1
Affiliations
Review

Autoimmune and other acquired neutropenias

Peter E Newburger. Hematology Am Soc Hematol Educ Program. .

Abstract

This educational review addresses the diagnostic evaluation of patients for autoimmune and other forms of acquired neutropenia, including the futility of deconstructing the overlap of chronic "autoimmune," "benign," and "idiopathic" categories. Isolated neutropenias caused by infection, drugs, and immunologic disorders are also addressed. Discussion of management options emphasizes a conservative approach, with largely supportive care for these mostly benign and self-limited disorders.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

Figure 1.
Figure 1.
Algorithm for the diagnosis of acquired neutropenia. “Anti-neutrophil antibody” is enclosed in parentheses to indicate that the test has limited utility (see text). abnl, abnormal; AML, acute myeloid leukemia; ANC, absolute neutrophil count; BMF, bone marrow failure; CBC, complete blood count; diff, differential count; Dx, diagnosis; Hx, history; Ig, immunoglobulins A, G, and M; LGL, large granular lymphocyte; MDS, myelodysplastic syndrome; NGS, next generation sequencing; Nl, normal; Sx, symptoms. “Severe phenotype” indicates severe, recurrent, or opportunistic infections. Adapted from Dinauer et al with permission.
See this image and copyright information in PMC

References

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