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. 2017 Feb 1;65(2):204-207.
doi: 10.1248/cpb.c16-00743. Epub 2016 Dec 3.

Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang  1 , Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Tuan Hiep, Nguyen Tien Dat
Affiliations
Free article

Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

Nguyen Hai Dang et al. Chem Pharm Bull (Tokyo). .
Free article

Abstract

A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B-D (2-4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC50 values ranging from 0.51 to 0.66 µM.

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