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Review
. 2016 Nov 30;9(4):75.
doi: 10.3390/ph9040075.

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

Madalina Elena Grigore  1 , Elena Ramona Biscu  2 , Alina Maria Holban  3   4 , Monica Cartelle Gestal  5 , Alexandru Mihai Grumezescu  6
Affiliations
Review

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

Madalina Elena Grigore et al. Pharmaceuticals (Basel). .

Abstract

This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.

Keywords: CuO; antimicrobial nanoparticles; biomedical nanostructures; synthesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Microscopic images of CuO NPs synthesized by a green method: (a) scanning electron microscopy (SEM) image; (b) EDAX spectrometry of the CuO NPs; inset: elemental mapping of oxygen and copper; (c–e) transmission electron microscopy (TEM) images at different magnifications; (f) high magnification view of the CuO NPs; and (g) Selected Area Electron Diffraction (SAED) pattern of the CuO NPs [39].
Figure 2
Figure 2
Toxicity mechanism of CuO nanoparticles in eukaryotic cells.
See this image and copyright information in PMC

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