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Review
. 2016 Nov 21:7:210.
doi: 10.3389/fneur.2016.00210. eCollection 2016.

Intracerebral Hemorrhage: Perihemorrhagic Edema and Secondary Hematoma Expansion: From Bench Work to Ongoing Controversies

Manoj K Mittal  1 , Aaron LacKamp  2
Affiliations
Review

Intracerebral Hemorrhage: Perihemorrhagic Edema and Secondary Hematoma Expansion: From Bench Work to Ongoing Controversies

Manoj K Mittal et al. Front Neurol. .

Abstract

Intracerebral hemorrhage (ICH) is a medical emergency, which often leads to severe disability and death. ICH-related poor outcomes are due to primary injury causing structural damage and mass effect and secondary injury in the perihemorrhagic region over several days to weeks. Secondary injury after ICH can be due to hematoma expansion (HE) or a consequence of repair pathway along the continuum of neuroinflammation, neuronal death, and perihemorrhagic edema (PHE). This review article is focused on PHE and HE and will cover the animal studies, related human studies, and clinical trials relating to these mechanisms of secondary brain injury in ICH patients.

Keywords: hematoma expansion; intracerebral hemorrhage; perihemorrhagic edema; secondary brain injury.

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References

    1. Hemphill JC, III, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2015) 46:2032–60.10.1161/STR.0000000000000069 - DOI - PubMed
    1. Mutlu N, Berry RG, Alpers BJ. Massive cerebral hemorrhage. Clinical and pathological correlations. Arch Neurol (1963) 8:644–61.10.1001/archneur.1963.00460060074008 - DOI - PubMed
    1. Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE, et al. Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter. Stroke (1996) 27:490–7.10.1161/01.STR.27.3.490 - DOI - PubMed
    1. Arima H, Wang JG, Huang Y, Heeley E, Skulina C, Parsons MW, et al. Significance of perihematomal edema in acute intracerebral hemorrhage: the INTERACT trial. Neurology (2009) 73:1963–8.10.1212/WNL.0b013e3181c55ed3 - DOI - PMC - PubMed
    1. Tomita H, Ito U, Ohno K, Hirakawa K. Chronological changes in brain edema induced by experimental intracerebral hematoma in cats. Acta Neurochir Suppl (Wien) (1994) 60:558–60. - PubMed