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Comparative Study
. 2016 Sep;16(3):766-771.
doi: 10.4314/ahs.v16i3.17.

Association of interleukin 17 / angiotensin II with refractory hypertension risk in hemodialysis patients

Zebin Wang  1 , Wei Shi  2 , Xinling Liang  2 , Wenjian Wang  2 , Jianbo Liang  3
Affiliations
Comparative Study

Association of interleukin 17 / angiotensin II with refractory hypertension risk in hemodialysis patients

Zebin Wang et al. Afr Health Sci. 2016 Sep.

Abstract

Objective: The study was performed to investigate the association of interleukin 17 (IL 17) or angiotensin II (Ang II) with refractory hypertension risk in hemodialysis patients.

Methods: Ninety hemodialysis patients were enrolled into this study, and those with hypertension were divided into two groups. The Easy-to-Control Hypertension group (ECHG) had fifty patients, while the refractory hypertension group (RHG) had forty patients. Twenty healthy individuals were recruited as the control group. IL17 and Ang II were determined using a human IL 17 / Ang II enzyme-linked immunosorbent assay kit. Serum IL 17 and Ang II concentrations in RHG patients were higher than those in ECHG patients.

Results: Serum IL 17 and Ang II concentrations in both patient groups were higher than those in the control group. Linear regression analysis showed a positive correlation between IL 17 and Ang II. In multivariate regression analysis, we found that IL17 and Ang II were associated with refractory hypertension risk in hemodialysis patients.

Conclusion: IL17 and Ang II were associated with refractory hypertension risk in hemodialysis patients. There was also a positive correlation between IL 17and Ang II.

Keywords: Angiotensin II; Interleukin 17; hemodialysis; refractory hypertension.

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Figures

Fig 1
Fig 1
Linear regression analysis showed correlation between angiotensin II , IL 17 and MAP. A. Linear regression analysis showed positive linear correlation between angiotensin II and IL 17, the regression coefficient(B) was 7.617(95%CI 6.969–8.264), t=23.375, p<0.01, R2=0.861. B. Linear regression analysis showed positive linear correlation between IL 17 and MPA, the regression co-efficient(B) was 0.081(95%CI 0.071–0.092), t=15.709, p<0.01, R2=0.737.
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References

    1. Tumwine JK. From renal and cardiovascular disease risk, to reproductive health, increasing violence in Nigeria and use of ultra sound in blunt trauma. Afr Health Sci. 2006;6(3):131. - PMC - PubMed
    1. Agarwal R, Nissenson AR, Batlle D, Coyne DW, Trout JR, Warnock DG. Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States. Am J Med. 2003;115(4):291–297. - PubMed
    1. Kaze FF, Kengne AP, Mambap AT, Halle MP, Mbanya D, Ashuntantang G. Anemia in patients on chronic hemodialysis in Cameroon: prevalence, characteristics and management in low resources setting. Afr Health Sci. 2015;15(1):253–260. - PMC - PubMed
    1. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE. Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease. Kidney Int. 1996;49(5):1379–1385. - PubMed
    1. Campese VM, Mitra N, Sandee D. Hypertension in renal parenchymal disease: why is it so resistant to treatment? Kidney Int. 2006;69(6):967–973. - PubMed

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