Comment on

• Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.

  Yamada M, Emmanuele V, Sanchez-Quintero MJ, Sun B, Lallos G, Paull D, Zimmer M, Pagett S, Prosser RW, Sauer MV, Hirano M, Egli D. Yamada M, et al. Cell Stem Cell. 2016 Jun 2;18(6):749-754. doi: 10.1016/j.stem.2016.04.001. Epub 2016 May 19. Cell Stem Cell. 2016. PMID: 27212703 Free PMC article.
• Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.

  Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M. Hyslop LA, et al. Nature. 2016 Jun 16;534(7607):383-6. doi: 10.1038/nature18303. Epub 2016 Jun 8. Nature. 2016. PMID: 27281217 Free PMC article.
• Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.

  Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Kang E, et al. Nature. 2016 Dec 8;540(7632):270-275. doi: 10.1038/nature20592. Epub 2016 Nov 30. Nature. 2016. PMID: 27919073