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Comment
. 2016 Dec;6(12):1309-1311.
doi: 10.1158/2159-8290.CD-16-1197.

Culprit or Bystander? The Role of the Fallopian Tube in "Ovarian" High-Grade Serous Carcinoma

Elizabeth M Swisher  1 , Rochelle L Garcia  2 , Mark R Kilgore  2 , Barbara M Norquist  3
Affiliations
Comment

Culprit or Bystander? The Role of the Fallopian Tube in "Ovarian" High-Grade Serous Carcinoma

Elizabeth M Swisher et al. Cancer Discov. 2016 Dec.

Abstract

The concurrence of intraepithelial high-grade neoplasia in the fallopian tube with metastatic implants has been taken as evidence of a tubal origin for high-grade serous pelvic carcinomas. In the current issue, Eckert and colleagues perform detailed genomic phylogenetic analyses and demonstrate that some cases of high-grade serous intraepithelial tubal neoplasia are metastatic implants and not precursor lesions. Cancer Discov; 6(12); 1309-11. ©2016 AACR.See related article by Eckert and colleagues, p. 1342.

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