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. 2016 Dec 15;214(suppl 5):S497-S499.
doi: 10.1093/infdis/jiw352.

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus

Adam D DeZure  1 , Nina M Berkowitz  1 , Barney S Graham  1 , Julie E Ledgerwood  1
Affiliations

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus

Adam D DeZure et al. J Infect Dis. .

Abstract

Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, stability, and delivery characteristics.

Keywords: alphavirus; chikungunya virus; vaccine; virus-like particle vaccine; whole-inactivated vaccine.

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References

    1. Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 2015; 372:1231–9. - PubMed
    1. Eckels KH, Harrison VR, Hetrick FM. Chikungunya virus vaccine prepared by Tween-ether extraction. Appl Microbiol 1970; 19:321–5. - PMC - PubMed
    1. Harrison VR, Binn LN, Randall R. Comparative immunogenicities of chikungunya vaccines prepared in avian and mammalian tissues. Am J Trop Med Hyg 1967; 16:786–91. - PubMed
    1. Harrison VR, Eckels KH, Bartelloni PJ, Hampton C. Production and evaluation of a formalin-killed chikungunya vaccine. J Immunol 1971; 107:643–7. - PubMed
    1. White A, Berman S, Lowenthal JP. Comparative immunogenicities of chikungunya vaccines propagated in monkey kidney monolayers and chick embryo suspension cultures. Appl Microbiol 1972; 23:951–2. - PMC - PubMed

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