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. 2016 Nov 24:13:33-38.
doi: 10.1016/j.nicl.2016.11.006. eCollection 2017.

Neurochemical changes in patients with chronic low back pain detected by proton magnetic resonance spectroscopy: A systematic review

Xianjing Zhao  1 , Maosheng Xu  1 , Kristen Jorgenson  2 , Jian Kong  2
Affiliations

Neurochemical changes in patients with chronic low back pain detected by proton magnetic resonance spectroscopy: A systematic review

Xianjing Zhao et al. Neuroimage Clin. .

Abstract

Background: Low back pain is a highly prevalent health problem around the world, affecting 50% to 85% of people at some point in life. The purpose of this systematic review is to summarize the previous proton magnetic resonance spectroscopy studies on brain chemical changes in patients with chronic low back pain (CLBP).

Methods: We identified relevant studies from a literature search of PubMed and EMBASE from 1980 to March 2016. Data extraction was performed on the subjects' characteristics, MRS methods, spectral analyses, cerebral metabolites and perceptual measurements.

Results: The review identified 9 studies that met the inclusion criteria, comprised of data on 135 CLBP subjects and 137 healthy controls. Seven of these studies reported statistically different neurochemical alterations in patients with CLBP. The results showed that compared to controls, CLBP patients showed reductions of 1) N-acetyl-aspartate (NAA) in the dorsolateral prefrontal cortex (DLPFC), right primary motor cortex, left somatosensory cortex (SSC), left anterior insula and anterior cingulate cortex (ACC); 2) glutamate in the ACC; 3) myo-inositol in the ACC and thalamus; 4) choline in the right SSC; and 5) glucose in the DLPFC.

Conclusion: This review provides evidence for alterations in the biochemical profile of the brain in patients with CLBP, which suggests that biochemical changes may play a significant role in the development and pathophysiology of CLBP and shed light on the development of new treatments for CLBP.

Keywords: Brain chemistry; Low back pain; Magnetic resonance imaging; Proton magnetic resonance spectroscopy; Systematic review.

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Figures

Fig. 1
Fig. 1
Flow diagram of search strategy. #220 publications were excluded because they were near-infrared spectroscopy, atomic spectroscopy, 31P MRS studies and so on. ##These 29 studies mainly focused on concentrations of metabolites in the spinal cord, paraspinal muscles and intervertebral discs of LBP patients.
Fig. 2
Fig. 2
Biochemical changes in brain regions of CLBP patients.
See this image and copyright information in PMC

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