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Case Reports
. 2016 Dec 1:10:38-41.
doi: 10.1016/j.eucr.2016.11.003. eCollection 2017 Jan.

Angiosarcoma of the Adrenal Gland Treated Using a Multimodal Approach

Jay G Fuletra  1 , Benjamin T Ristau  1 , Barton Milestone  2 , Harry S Cooper  3 , Alysia Browne  3 , Sujana Movva  4 , Thomas J Galloway  5 , Randall Lee  1 , Nikhil Waingankar  1 , Alexander Kutikov  1
Affiliations
Case Reports

Angiosarcoma of the Adrenal Gland Treated Using a Multimodal Approach

Jay G Fuletra et al. Urol Case Rep. .

Abstract

Angiosarcoma of the adrenal gland is an extremely rare malignancy. We report a case of a 59-year-old female who presented with abdominal pain and profound anemia. A 7 cm enhancing, lipid-poor adrenal mass with calcifications that extended posterior to the vena cava was identified on imaging. Patient underwent right adrenalectomy with retroperitoneal lymph node dissection. Pathology demonstrated angiosarcoma of the adrenal gland. Consolidative treatment included adjuvant radiation and chemotherapy. Patient remains disease free 1.5 years following treatment. Prior reported literature on the diagnosis and management of adrenal angiosarcoma is reviewed.

Keywords: Adjuvant chemotherapy; Adjuvant radiation; Adrenal cancer; Angiosarcoma.

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Figures

Figure 1
Figure 1
Enhancing, lipid-poor mass with coarse areas of calcification measuring 7.0 × 6.7 cm in the right adrenal gland. Note relationship of the mass to the vena cava.
Figure 2
Figure 2
(A) Angiosarcoma of the adrenal gland. High power magnification demonstrates a sheet of large pleomorphic, round epithelioid cells with eosinophilic cytoplasm and large hyperchromatic nuclei with prominent nucleoli. Scattered intracytoplasmic lumina contain erythrocytes. Numerous mitotic figures are present (H & E, 40× magnification). (B) CD31 immunohistochemical stain. Diffuse intense membranous and cytoplasmic tumor cell staining with this vascular marker is apparent. (40× magnification).
See this image and copyright information in PMC

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