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Clinical Trial
. 1989;37(2):151-3.
doi: 10.1007/BF00558223.

Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function

S H Sindrup  1 , B Ejlertsen, A Frøland, E H Sindrup, K Brøsen, L F Gram
Affiliations
Clinical Trial

Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function

S H Sindrup et al. Eur J Clin Pharmacol. 1989.

Abstract

The effect of imipramine on symptomatic peripheral diabetic neuropathy in 9 patients was examined in a double-blind cross-over study against placebo. The dose of imipramine was adjusted to yield optimal plasma levels of imipramine plus desipramine of 300-750 nM. Imipramine had a clear beneificial effect on the symptoms of the neuropathy, whereas no changes in a range of neurophysiological measurement was detected. Despite some adverse effects, especially of an anticholinergic nature, the patients generally preferred imipramine to placebo.

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References

    1. JAMA. 1986 Feb 7;255(5):637-9 - PubMed
    1. Eur J Clin Pharmacol. 1986;30(6):679-84 - PubMed
    1. Metabolism. 1986 Mar;35(3):224-34 - PubMed
    1. Diabet Med. 1985 Sep;2(5):363-6 - PubMed
    1. JAMA. 1984 Apr 6;251(13):1727-30 - PubMed

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