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Comment
. 2016 Dec 6;22(12):1389-1390.
doi: 10.1038/nm.4243.

Spermidine to the rescue for an aging heart

Rafael de Cabo  1 , Pácido Navas  2
Affiliations
Comment

Spermidine to the rescue for an aging heart

Rafael de Cabo et al. Nat Med. .

Abstract

A recent study shows that spermidine has beneficial effects on health and lifespan in mice, and that these effects are the result of improved cardiovascular function. Similar effects of spermidine on humans are supported by epidemiological studies.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
The effects of spermidine on aging and cardiovascular health. (a) Aging increases the risk of cardiovascular disease, which manifests as increased hypertrophy and decreased diastolic function. (b) Eisenberg et al. show that dietary supplementation of mice with spermidine decreases the risk of CVD and death upon aging via an increase in autophagy, which results in increased cardiomyocyte fitness.
See this image and copyright information in PMC

Comment on

  • Cardioprotection and lifespan extension by the natural polyamine spermidine.
    Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.

References

    1. Eisenberg T, et al. Nat Med. 2016;22:1428–1438. - PMC - PubMed
    1. Pegg AE. J Biol Chem. 2016;291:14904–14912. - PMC - PubMed
    1. Eisenberg T, et al. Nat. Cell Biol. 2009;11:1305–1314. - PubMed
    1. Taneike M, et al. Autophagy. 2010;6:600–606. - PubMed
    1. de Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. Cell. 2014;157:1515–1526. - PMC - PubMed

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