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. 2017 Jun;139(6):1990-1992.e2.
doi: 10.1016/j.jaci.2016.10.027. Epub 2016 Dec 3.

Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

Eugene H Chang  1 , Amanda L Willis  2 , Hilary C McCrary  2 , George T Noutsios  2 , Christopher H Le  2 , Alexander G Chiu  2 , Corrine J Mansfield  3 , Danielle R Reed  3 , Steven G Brooks  4 , Nithin D Adappa  4 , James N Palmer  4 , Noam G Cohen  5 , Debra A Stern  6 , Stefano Guerra  6 , Fernando D Martinez  6
Affiliations

Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

Eugene H Chang et al. J Allergy Clin Immunol. 2017 Jun.

Abstract

A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.

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Figures

Figure 1
Figure 1
Meta-analysis of rs6967330 from UofA and UPenn. The rs6967330 SNP is significantly associated with CRS in both additive and dominant models. This association remains significant in those without self-reported asthma (non-asthmatics). mOR was adjusted for sex and age.
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