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. 2017 Apr;17(2):149-153.
doi: 10.1136/practneurol-2016-001428. Epub 2016 Dec 7.

Internuclear ophthalmoplegia

Jonathan D Virgo  1   2 , Gordon T Plant  1   2   3
Affiliations

Internuclear ophthalmoplegia

Jonathan D Virgo et al. Pract Neurol. 2017 Apr.

Abstract

A brainstem lesion of any type that involves the medial longitudinal fasciculus (MLF) can cause internuclear ophthalmoplegia (INO). This primarily affects conjugate horizontal gaze and classically manifests as impaired adduction ipsilateral to the lesion and abduction nystagmus contralateral to the lesion. Here, we describe the anatomy of the MLF and review the clinical features of INO. We also describe conjugate horizontal gaze palsy and some of the 'INO-plus' syndromes.

Keywords: Internuclear ophthalmoplegia; medial longitudinal fasciculus.

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