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Review
. 2016 Dec;16(6):576-579.
doi: 10.7861/clinmedicine.16-6-576.

Immunoglobulin therapy

Affiliations
Review

Immunoglobulin therapy

Sarah Louise Johnston et al. Clin Med (Lond). 2016 Dec.

Abstract

Immunoglobulin is an expensive blood product of potentially limited supply used in a wide variety of medical conditions, across a number of specialties. Historically, immunoglobulin has been associated with transmission of blood borne infection (eg hepatitis C). Immunoglobulin use needs to be carefully considered, appropriately prescribed and recorded. The Department of Health, in conjunction with relevant stakeholders, has established a demand management programme to secure immunoglobulin supplies for patients most in need of treatment and to limit use for indications where evidence is lacking.

Keywords: Blood product; demand management; immunoglobulin; immunomodulatory; replacement.

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Figures

Fig 1.
Fig 1.
Thoracic computerised tomography confirming extensive bronchiectasis, as evidenced by cylindrical and more peripheral airway dilatation with bronchial wall thickening, in a patient with primary antibody deficiencyAu: Provide a high resolution (300 dpi) copy of Fig 1 ?>.
Fig 2.
Fig 2.
Number of patients treated by specialty 2010–2015. Data from MDSAS.

References

    1. Albin S. Cunningham-Rundles C. An update on the use of immunoglobulin for the treatment of immunodeficiency disorders. Immunotherapy. 2014;6:1113–26. - PMC - PubMed
    1. Lucas M. Lee M. Lortan J, et al. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J Allergy Clin Immunol. 2010;125:1354–60.e4. - PubMed
    1. Matucci A. Maggi E. Vultaggio A. Mechanisms of action of Ig preparations: immunomodulatory and anti-inflammatory effects. Front Immunol. 2015;5:690. - PMC - PubMed
    1. Hadden RD. Marreno F. Switch from intravenous to subcutaneous immunoglobulin in CIDP and MMN: improved tolerability and patient satisfaction. Ther Adv Neurol Disord. 2015;8:14–9. - PMC - PubMed
    1. Cherin P. Belizna C. Cartry O, et al. Long-term subcutaneous immunoglobulin use in inflammatory myopathies: A retrospective review of 19 cases. Autoimmun Rev. 2016;15:281–6. - PubMed

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