Defibrotide
- PMID: 27928191
- PMCID: PMC5135434
- DOI: 10.1310/hpj5110-847
Defibrotide
Abstract
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433. The November 2016 monograph topics are apaziquone, crisaborole, irinotecan liposome, plecanatide, and telotristat. The Safety MUE is on methylnaltrexone PO.
References
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- Defitelio (defibrotide sodium) [prescribing information]. Palo Alto, CA: Jazz Pharmaceuticals; March 2016.
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- Platzbecker U, Bornhäuser M. SOS for veno-occlusive disease: Defibrotide prophylaxis. Lancet. 2012; 379( 9823): 1277– 1278. - PubMed
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- Zhang L, Wang Y, Huang H. Defibrotide for the prevention of hepatic veno-occlusive disease after hematopoietic stem cell transplantation: A systematic review. Clin Transplant. 2012; 26( 4): 511– 519. - PubMed
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- Hopps SA, Borders EB, Hagemann TM. Prophylaxis and treatment recommendations for sinusoidal obstruction syndrome in adult and pediatric patients undergoing hematopoietic stem cell transplant: A review of the literature [published online ahead of print June 30, 2015]. J Oncol Pharm Pract. 2016; 22( 3): 496– 510. - PubMed
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