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Case Reports
. 2014 Sep 19;38(5):268-271.
doi: 10.3109/01658107.2014.924968. eCollection 2014.

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Oscar Jim Michael Coppes  1 , Rimas V Lukas  2 , Gini F Fleming  3 , Jeffrey Nichols  4 , Meaghan Tenney  5 , Jacqueline Bernard  2
Affiliations
Case Reports

Bilateral Optic Disc Swelling Following Anastrozole Therapy

Oscar Jim Michael Coppes et al. Neuroophthalmology. .

Abstract

A 56-year-old female with early-stage breast cancer, stage IA grade 1 endometrial cancer, and stage IC grade 1 ovarian cancer developed sudden-onset visual changes and right inferior visual field defect following anastrozole therapy. Examination revealed severe bilateral optic disc swelling and impaired visual acuity. Laboratory work-up was otherwise unremarkable. Anastrozole was discontinued and over the next month, patient had near-complete resolution of swelling in the right eye and improvement in the left eye. This is the only reported case of optic disc swelling following anastrozole therapy.

Keywords: Breast neoplasms; chemotherapy; optical coherence tomography; papilloedema; vision.

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Figures

FIGURE 1
FIGURE 1
Sequential OCT scans showing increased RNFL thickness and subsequent resolution. First row: 14 May 2012; second row: 11 June 2012; third row: 9 January 2013.
See this image and copyright information in PMC

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