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Case Reports
. 2015 Nov 10;39(6):285-288.
doi: 10.3109/01658107.2015.1084332. eCollection 2015 Dec.

Anti-MOG (Myelin Oligodendrocyte Glycoprotein)-Positive Severe Optic Neuritis with Optic Disc Ischaemia and Macular Star

Frederico Castelo Moura  1 , Douglas Kazutoshi Sato  2 , Carolina Medeiros Rimkus  3 , Samira Luisa Apóstolos-Pereira  4 , Luana Michelli de Oliveira  4 , Claudia Costa Leite  3 , Kazuo Fujihara  5 , Mario Luiz Ribeiro Monteiro  1 , Dagoberto Callegaro  4
Affiliations
Case Reports

Anti-MOG (Myelin Oligodendrocyte Glycoprotein)-Positive Severe Optic Neuritis with Optic Disc Ischaemia and Macular Star

Frederico Castelo Moura et al. Neuroophthalmology. .

Abstract

A 44-year-old man presented with severe right visual loss. The right fundus examination showed marked optic disc oedema associated with partial macular star. Serological blood tests for infectious agents were all negative. Serum aquaporin-4 antibody was negative but anti-MOG (myelin oligodendrocyte glycoprotein) was positive. Magnetic resonance revealed extensive lesion in right optic nerve. There was no visual improvement after intravenous therapy. Patient had no further attacks after follow-up. Optic disc oedema with macular star is found in several infectious and non-inflammatory disorders, but it has not been reported in optic neuritis (ON) associated with autoantibodies to myelin oligodendrocyte glycoprotein (anti-MOG).

Keywords: Devic’s syndrome; macular star; multiple sclerosis; myelin oligodendrocyte glycoprotein antibody; optic neuritis.

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Figures

FIGURE 1
FIGURE 1
(Upper panels) Colour fundus view of right eye at admission (A) shows optic disc oedema with macular star (arrows) and (B) remarkable improvement of the optic disc oedema and macular star (arrow) 10 days after treatment. (Lower panels) Orbital magnetic resonance imaging shows a (C) T2-weighted hyperintense extensive lesion (arrows) in the right optic nerve with T1-weighted sequence contrast enhancement (D; arrow).
See this image and copyright information in PMC

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