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Review
. 2016 Dec 6;17(12):2044.
doi: 10.3390/ijms17122044.

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Claudia R L Cardoso  1 , Gil F Salles  2
Affiliations
Review

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Claudia R L Cardoso et al. Int J Mol Sci. .

Abstract

Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.

Keywords: arterial stiffness; carotid-femoral pulse wave velocity; microvascular and macrovascular complications; type 2 diabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the potential physiopathological pathways involved in the relationships between increased aortic stiffness and micro- and macrovascular complications in diabetes.
See this image and copyright information in PMC

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