Breastfeeding associated with higher lung function in African American youths with asthma

doi:10.1080/02770903.2016.1266496

. 2017 Oct;54(8):856-865.

doi: 10.1080/02770903.2016.1266496. Epub 2016 Dec 8.

Breastfeeding associated with higher lung function in African American youths with asthma

Sam S Oh¹, Randal Du^{1

2}, Andrew M Zeiger¹, Meghan E McGarry³, Donglei Hu¹, Neeta Thakur¹, Maria Pino-Yanes⁴, Joshua M Galanter^{1

5}, Celeste Eng¹, Katherine Keiko Nishimura¹, Scott Huntsman¹, Harold J Farber^{6

7}, Kelley Meade⁸, Pedro Avila⁹, Denise Serebrisky¹⁰, Kirsten Bibbins-Domingo¹, Michael A Lenoir¹¹, Jean G Ford¹², Emerita Brigino-Buenaventura¹³, William Rodriguez-Cintron¹⁴, Shannon M Thyne¹⁵, Saunak Sen¹⁶, Jose R Rodriguez-Santana¹⁷, Keoki Williams^{18

19}, Rajesh Kumar⁹, Esteban G Burchard^{1

5}

Affiliations

¹ a Department of Medicine , University of California San Francisco , San Francisco , CA , USA.
² b Department of Pharmacy , University of California San Francisco , San Francisco , CA , USA.
³ c Department of Pediatrics , University of California San Francisco , San Francisco , CA , USA.
⁴ d Research Unit , Hospital Universitario NS de Candelaria , Santa Cruz de Tenerife , Spain.
⁵ e Department of Bioengineering and Therapeutic Sciences , University of California San Franscisco , San Francisco , CA , USA.
⁶ f Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA.
⁷ g Department of Pulmonology , Texas Children's Hospital , Houston , TX , USA.
⁸ h Department of Primary Care , UCSF Benioff Children's Hospital , San Francisco , CA , USA.
⁹ i Department of Medicine , Northwestern University , Evanston , IL , USA.
¹⁰ j Department of Pediatric Pulmonology , Jacobi Medical Center , Bronx , NY , USA.
¹¹ k Department of Pediatrics , Bay Area Pediatrics , Oakland , CA , USA.
¹² l Department of Epidemiology , Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD , USA.
¹³ m Department of Allergy and Immunology , Kaiser Permanente Vallejo Medical Center , San Francisco , CA , USA.
¹⁴ n Department of Pulmonary/Critica Care , VA Caribbean Healthcare System , San Juan , Puerto Rico.
¹⁵ o Department of Medicine , University of California Los Angeles David Geffen School of Medicine , Los Angeles , CA , USA.
¹⁶ p Department of Epidemiology and Biostatistics , University of California San Francisco , San Francisco , CA , USA.
¹⁷ q Department of Pediatric Pulmonology and Critical Care , Centro de Neumología Pediátrica , San Juan , Puerto Rico.
¹⁸ r Center for Health Policy and Health Services Research, Henry Ford Health System , Detroit , MI , USA.
¹⁹ s Department of Internal Medicine , Henry Ford Health System , Detroit , MI , USA.

PMID: 27929698
PMCID: PMC6130885
DOI: 10.1080/02770903.2016.1266496

Breastfeeding associated with higher lung function in African American youths with asthma

Sam S Oh et al. J Asthma. 2017 Oct.

. 2017 Oct;54(8):856-865.

doi: 10.1080/02770903.2016.1266496. Epub 2016 Dec 8.

Authors

Affiliations

¹ a Department of Medicine , University of California San Francisco , San Francisco , CA , USA.
² b Department of Pharmacy , University of California San Francisco , San Francisco , CA , USA.
³ c Department of Pediatrics , University of California San Francisco , San Francisco , CA , USA.
⁴ d Research Unit , Hospital Universitario NS de Candelaria , Santa Cruz de Tenerife , Spain.
⁵ e Department of Bioengineering and Therapeutic Sciences , University of California San Franscisco , San Francisco , CA , USA.
⁶ f Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA.
⁷ g Department of Pulmonology , Texas Children's Hospital , Houston , TX , USA.
⁸ h Department of Primary Care , UCSF Benioff Children's Hospital , San Francisco , CA , USA.
⁹ i Department of Medicine , Northwestern University , Evanston , IL , USA.
¹⁰ j Department of Pediatric Pulmonology , Jacobi Medical Center , Bronx , NY , USA.
¹¹ k Department of Pediatrics , Bay Area Pediatrics , Oakland , CA , USA.
¹² l Department of Epidemiology , Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD , USA.
¹³ m Department of Allergy and Immunology , Kaiser Permanente Vallejo Medical Center , San Francisco , CA , USA.
¹⁴ n Department of Pulmonary/Critica Care , VA Caribbean Healthcare System , San Juan , Puerto Rico.
¹⁵ o Department of Medicine , University of California Los Angeles David Geffen School of Medicine , Los Angeles , CA , USA.
¹⁶ p Department of Epidemiology and Biostatistics , University of California San Francisco , San Francisco , CA , USA.
¹⁷ q Department of Pediatric Pulmonology and Critical Care , Centro de Neumología Pediátrica , San Juan , Puerto Rico.
¹⁸ r Center for Health Policy and Health Services Research, Henry Ford Health System , Detroit , MI , USA.
¹⁹ s Department of Internal Medicine , Henry Ford Health System , Detroit , MI , USA.

PMID: 27929698
PMCID: PMC6130885
DOI: 10.1080/02770903.2016.1266496

Abstract

Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV₁) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma.

Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8-21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV¹% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations.

Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV₁% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only.

Conclusion: Breastfeeding was associated with higher FEV₁% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

Keywords: Asthma; Hispanics; breastfeeding; exacerbations; genetic admixture; lung function; minority.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Figures

**Figure 1.. Association between breastfeeding and FEV₁ % predicted among youths with asthma in Study A and Study B: 2008–2014.**
Estimates adjusted for proportion of Native American ancestry for Latinos, proportion of African ancestry for African Americans, body mass index category, socioeconomic status, total IgE levels, family history of asthma, chest illnesses before age of 2, maternal prenatal smoking, birth weight, recruitment center and sex.

See this image and copyright information in PMC

Cited by

Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis.
Perikleous E, Fouzas S, Karageorgiou A, Steiropoulos P, Nena E, Chatzimichael A, Tsalkidis A, Paraskakis E. Perikleous E, et al. World J Clin Pediatr. 2021 Nov 9;10(6):168-176. doi: 10.5409/wjcp.v10.i6.168. eCollection 2021 Nov 9. World J Clin Pediatr. 2021. PMID: 34868893 Free PMC article.
Association between History of Prolonged Exclusive Breast-Feeding and the Lung Function Indices in Childhood.
Perikleous EP, Fouzas S, Michailidou M, Patsourou A, Tsalkidis D, Steiropoulos P, Nena E, Chatzimichael A, Paraskakis E. Perikleous EP, et al. Children (Basel). 2022 Nov 8;9(11):1708. doi: 10.3390/children9111708. Children (Basel). 2022. PMID: 36360436 Free PMC article.
Human Milk and Allergic Diseases: An Unsolved Puzzle.
Munblit D, Peroni DG, Boix-Amorós A, Hsu PS, Van't Land B, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, Warner JO. Munblit D, et al. Nutrients. 2017 Aug 17;9(8):894. doi: 10.3390/nu9080894. Nutrients. 2017. PMID: 28817095 Free PMC article. Review.
Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children.
Zhang C, Guo Y, Xiao X, Bloom MS, Qian Z, Rolling CA, Xian H, Lin S, Li S, Chen G, Jalava P, Roponen M, Hirvonen MR, Komppula M, Leskinen A, Yim SHL, Chen DH, Ma H, Zeng XW, Hu LW, Liu KK, Yang BY, Dong GH. Zhang C, et al. JAMA Netw Open. 2019 May 3;2(5):e194186. doi: 10.1001/jamanetworkopen.2019.4186. JAMA Netw Open. 2019. PMID: 31125097 Free PMC article.
Early life obesity increases the risk for asthma in San Francisco born Latina girls.
McCallister M, Medrano R, Wojcicki J. McCallister M, et al. Allergy Asthma Proc. 2018 Jul 1;39(4):273-280. doi: 10.2500/aap.2018.39.4125. Allergy Asthma Proc. 2018. PMID: 30095392 Free PMC article.

References

1. Bhan N, Kawachi I, Glymour MM, Subramanian SV. Time Trends in Racial and Ethnic Disparities in Asthma Prevalence in the United States From the Behavioral Risk Factor Surveillance System (BRFSS) Study (1999–2011). Am J Public Health 2015. June;105(6):1269–75. - PMC - PubMed
1. Barr RG, Avilés-Santa L, Davis SM, Aldrich TK, Gonzalez F, Henderson AG, et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 2016. February 15;193(4):386–95. - PMC - PubMed
1. Homa DM, Mannino DM, Lara M. Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990–1995. Am J Respir Crit Care Med 2000. February; 161(2 Pt 1):504–9. - PubMed
1. American Lung Association, Epidemiology and Statistics Unit. Trends in Asthma Morbidity and Mortality American Lung Association; 2005. 1 p.
1. Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Thorax 2001. March;56(3):192–7. - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Consumer Health Information
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program

[1] Bhan N, Kawachi I, Glymour MM, Subramanian SV. Time Trends in Racial and Ethnic Disparities in Asthma Prevalence in the United States From the Behavioral Risk Factor Surveillance System (BRFSS) Study (1999–2011). Am J Public Health 2015. June;105(6):1269–75. - PMC - PubMed

[2] Bhan N, Kawachi I, Glymour MM, Subramanian SV. Time Trends in Racial and Ethnic Disparities in Asthma Prevalence in the United States From the Behavioral Risk Factor Surveillance System (BRFSS) Study (1999–2011). Am J Public Health 2015. June;105(6):1269–75. - PMC - PubMed

[3] Barr RG, Avilés-Santa L, Davis SM, Aldrich TK, Gonzalez F, Henderson AG, et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 2016. February 15;193(4):386–95. - PMC - PubMed

[4] Barr RG, Avilés-Santa L, Davis SM, Aldrich TK, Gonzalez F, Henderson AG, et al. Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med 2016. February 15;193(4):386–95. - PMC - PubMed

[5] Homa DM, Mannino DM, Lara M. Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990–1995. Am J Respir Crit Care Med 2000. February; 161(2 Pt 1):504–9. - PubMed

[6] Homa DM, Mannino DM, Lara M. Asthma mortality in U.S. Hispanics of Mexican, Puerto Rican, and Cuban heritage, 1990–1995. Am J Respir Crit Care Med 2000. February; 161(2 Pt 1):504–9. - PubMed

[7] American Lung Association, Epidemiology and Statistics Unit. Trends in Asthma Morbidity and Mortality American Lung Association; 2005. 1 p.

[8] American Lung Association, Epidemiology and Statistics Unit. Trends in Asthma Morbidity and Mortality American Lung Association; 2005. 1 p.

[9] Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Thorax 2001. March;56(3):192–7. - PMC - PubMed

[10] Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Thorax 2001. March;56(3):192–7. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Breastfeeding associated with higher lung function in African American youths with asthma

Affiliations

Breastfeeding associated with higher lung function in African American youths with asthma

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials