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. 2017 Feb 1;215(3):415-419.
doi: 10.1093/infdis/jiw566.

Reduced Transplacental Transfer of Group B Streptococcus Surface Protein Antibodies in HIV-infected Mother-Newborn Dyads

Sonwabile Dzanibe  1   2 , Peter V Adrian  1   2 , Sheila Z Kimaro Mlacha  1   2 , Ziyaad Dangor  1   2   3 , Gaurav Kwatra  1   2 , Shabir A Madhi  1   2   4
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Reduced Transplacental Transfer of Group B Streptococcus Surface Protein Antibodies in HIV-infected Mother-Newborn Dyads

Sonwabile Dzanibe et al. J Infect Dis. .

Abstract

We evaluated the effect of maternal HIV infection on transplacental antibody transfer specific to 8 group B Streptococcus (GBS) surface proteins among 81 HIV-uninfected and 83 HIV-infected mother-newborn pairs using a multiplex immunoassay. Significantly lower antibody titers were detected in HIV-infected mothers and HIV-exposed uninfected newborns compared to HIV-uninfected mother-newborn dyads. Maternal HIV infection was also associated with reduced transplacental transfer of antibodies for Sip (25.8%), Foldase (30.4%), gba0392 (36.5%), gbs0393 (32.9%), gbs1539 (39.2%), gbs2106 (35.7%), and BibA (19.4%); P < .003. This reduced transplacental antibody might contribute to increased susceptibility for invasive GBS disease in HIV-exposed uninfected infants.

Keywords: HIV; antibodies; group B Streptococcus; surface proteins; trans-placental transfer.

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