Can T cells be too exhausted to fight back?

doi:10.1126/science.aal3204

Comment

. 2016 Dec 2;354(6316):1104-1105.

doi: 10.1126/science.aal3204.

Can T cells be too exhausted to fight back?

Stephen J Turner¹, Brendan E Russ²

Affiliations

¹ Department of Microbiology, Biomedical Discovery Institute, Monash University, Australia. stephen.j.turner@monash.edu.
² Department of Microbiology, Biomedical Discovery Institute, Monash University, Australia.

PMID: 27934723
DOI: 10.1126/science.aal3204

Comment

Can T cells be too exhausted to fight back?

Stephen J Turner et al. Science. 2016.

. 2016 Dec 2;354(6316):1104-1105.

doi: 10.1126/science.aal3204.

Authors

Stephen J Turner¹, Brendan E Russ²

Affiliations

¹ Department of Microbiology, Biomedical Discovery Institute, Monash University, Australia. stephen.j.turner@monash.edu.
² Department of Microbiology, Biomedical Discovery Institute, Monash University, Australia.

PMID: 27934723
DOI: 10.1126/science.aal3204

No abstract available

PubMed Disclaimer

Comment on

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.
Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. Pauken KE, et al. Science. 2016 Dec 2;354(6316):1160-1165. doi: 10.1126/science.aaf2807. Epub 2016 Oct 27. Science. 2016. PMID: 27789795 Free PMC article.
The epigenetic landscape of T cell exhaustion.
Sen DR, Kaminski J, Barnitz RA, Kurachi M, Gerdemann U, Yates KB, Tsao HW, Godec J, LaFleur MW, Brown FD, Tonnerre P, Chung RT, Tully DC, Allen TM, Frahm N, Lauer GM, Wherry EJ, Yosef N, Haining WN. Sen DR, et al. Science. 2016 Dec 2;354(6316):1165-1169. doi: 10.1126/science.aae0491. Epub 2016 Oct 27. Science. 2016. PMID: 27789799 Free PMC article.

Cited by

Mucosal and systemic SIV-specific cytotoxic CD4⁺ T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques.
Khanna M, Jackson RJ, Alcantara S, Amarasena TH, Li Z, Kelleher AD, Kent SJ, Ranasinghe C. Khanna M, et al. Sci Rep. 2019 Apr 5;9(1):5661. doi: 10.1038/s41598-019-41506-5. Sci Rep. 2019. PMID: 30952887 Free PMC article.
Application of ATAC-seq in tumor-specific T cell exhaustion.
Chen C, Liu J, Chen Y, Lin A, Mou W, Zhu L, Yang T, Cheng Q, Zhang J, Luo P. Chen C, et al. Cancer Gene Ther. 2023 Jan;30(1):1-10. doi: 10.1038/s41417-022-00495-w. Epub 2022 Jul 6. Cancer Gene Ther. 2023. PMID: 35794339 Free PMC article. Review.
Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery.
Nidetz NF, McGee MC, Tse LV, Li C, Cong L, Li Y, Huang W. Nidetz NF, et al. Pharmacol Ther. 2020 Mar;207:107453. doi: 10.1016/j.pharmthera.2019.107453. Epub 2019 Dec 11. Pharmacol Ther. 2020. PMID: 31836454 Free PMC article. Review.
Exhaustion-associated regulatory regions in CD8⁺ tumor-infiltrating T cells.
Mognol GP, Spreafico R, Wong V, Scott-Browne JP, Togher S, Hoffmann A, Hogan PG, Rao A, Trifari S. Mognol GP, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2776-E2785. doi: 10.1073/pnas.1620498114. Epub 2017 Mar 10. Proc Natl Acad Sci U S A. 2017. PMID: 28283662 Free PMC article.
Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy.
Lee JB, Kim HR, Ha SJ. Lee JB, et al. Immune Netw. 2022 Feb 14;22(1):e2. doi: 10.4110/in.2022.22.e2. eCollection 2022 Feb. Immune Netw. 2022. PMID: 35291660 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Atypon
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Can T cells be too exhausted to fight back?

Affiliations

Can T cells be too exhausted to fight back?

Authors

Affiliations

Comment on

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources