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• Pronounced electronic modulation of geometrically-regulated metalloenediyne cyclization.

  Lindahl SE, Metzger EM, Chen CH, Pink M, Zaleski JM. Lindahl SE, et al. Chem Sci. 2024 Nov 12;16(1):255-279. doi: 10.1039/d4sc05396f. eCollection 2024 Dec 18. Chem Sci. 2024. PMID: 39605870 Free PMC article.
• Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships.

  Steele AD, Kiefer AF, Hwang D, Yang D, Teijaro CN, Adhikari A, Rader C, Shen B. Steele AD, et al. J Med Chem. 2023 Jan 26;66(2):1562-1573. doi: 10.1021/acs.jmedchem.2c01771. Epub 2023 Jan 4. J Med Chem. 2023. PMID: 36599039 Free PMC article.
• Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.

  Adhikari A, Teijaro CN, Yan X, Chang CY, Gui C, Liu YC, Crnovcic I, Yang D, Annaval T, Rader C, Shen B. Adhikari A, et al. J Med Chem. 2020 Aug 13;63(15):8432-8441. doi: 10.1021/acs.jmedchem.0c00799. Epub 2020 Jul 24. J Med Chem. 2020. PMID: 32658465 Free PMC article.
• Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes.

  Wender PA, Kelly RC, Beckham S, Miller BL. Wender PA, et al. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8835-9. doi: 10.1073/pnas.88.19.8835. Proc Natl Acad Sci U S A. 1991. PMID: 1924343 Free PMC article.
• Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.

  Yan X, Chen JJ, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B. Yan X, et al. Org Lett. 2018 Sep 21;20(18):5918-5921. doi: 10.1021/acs.orglett.8b02584. Epub 2018 Sep 13. Org Lett. 2018. PMID: 30212211 Free PMC article.