Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Nov 14;37(43):3279-3281.
doi: 10.1093/eurheartj/ehw498. Epub 2016 Oct 25.

Genetic cardiovascular risk prediction: are we already there?

Themistocles L Assimes  1 , Benjamin A Goldstein  2   3
Affiliations
Editorial

Genetic cardiovascular risk prediction: are we already there?

Themistocles L Assimes et al. Eur Heart J. .
No abstract available

PubMed Disclaimer

Comment on

  • Genomic prediction of coronary heart disease.
    Abraham G, Havulinna AS, Bhalala OG, Byars SG, De Livera AM, Yetukuri L, Tikkanen E, Perola M, Schunkert H, Sijbrands EJ, Palotie A, Samani NJ, Salomaa V, Ripatti S, Inouye M. Abraham G, et al. Eur Heart J. 2016 Nov 14;37(43):3267-3278. doi: 10.1093/eurheartj/ehw450. Epub 2016 Sep 21. Eur Heart J. 2016. PMID: 27655226 Free PMC article.

References

    1. Visscher PM Brown MA McCarthy MI Yang J. Five years of GWAS discovery. Am J Hum Genet 2012;90:7–24. - PMC - PubMed
    1. CARDIoGRAMplusC4D Consortium, Deloukas P Kanoni S Willenborg C Farrall M Assimes TL Thompson JR Ingelsson E Saleheen D Erdmann J Goldstein BA Stirrups K Konig IR Cazier JB Johansson A Hall AS Lee JY Willer CJ Chambers JC Esko T Folkersen L Goel A Grundberg E Havulinna AS Ho WK Hopewell JC Eriksson N Kleber ME Kristiansson K Lundmark P Lyytikainen LP Rafelt S Shungin D Strawbridge RJ Thorleifsson G Tikkanen E Van Zuydam N Voight BF Waite LL Zhang W Ziegler A Absher D Altshuler D Balmforth AJ Barroso I Braund PS Burgdorf C Claudi-Boehm S Cox D Dimitriou M Do R Consortium D Consortium C Doney AS El Mokhtari N Eriksson P Fischer K Fontanillas P Franco-Cereceda A Gigante B Groop L Gustafsson S Hager J Hallmans G Han BG Hunt SE Kang HM Illig T Kessler T Knowles JW Kolovou G Kuusisto J Langenberg C Langford C Leander K Lokki ML Lundmark A McCarthy MI Meisinger C Melander O Mihailov E Maouche S Morris AD Muller-Nurasyid M Mu TC Nikus K Peden JF Rayner NW Rasheed A Rosinger S Rubin D Rumpf MP Schafer A Sivananthan M Song C Stewart AF Tan ST Thorgeirsson G van der Schoot CE Wagner PJ Wellcome Trust Case Control C Wells GA Wild PS Yang TP Amouyel P Arveiler D Basart H Boehnke M Boerwinkle E Brambilla P Cambien F Cupples AL de Faire U Dehghan A Diemert P Epstein SE Evans A Ferrario MM Ferrieres J Gauguier D Go AS Goodall AH Gudnason V Hazen SL Holm H Iribarren C Jang Y Kahonen M Kee F Kim HS Klopp N Koenig W Kratzer W Kuulasmaa K Laakso M Laaksonen R Lee JY Lind L Ouwehand WH Parish S Park JE Pedersen NL Peters A Quertermous T Rader DJ Salomaa V Schadt E Shah SH Sinisalo J Stark K Stefansson K Tregouet DA Virtamo J Wallentin L Wareham N Zimmermann ME Nieminen MS Hengstenberg C Sandhu MS Pastinen T Syvanen AC Hovingh GK Dedoussis G Franks PW Lehtimaki T Metspalu A Zalloua PA Siegbahn A Schreiber S Ripatti S Blankenberg SS Perola M Clarke R Boehm BO O’Donnell C Reilly MP Marz W Collins R Kathiresan S Hamsten A Kooner JS Thorsteinsdottir U Danesh J Palmer CN Roberts R Watkins H Schunkert H Samani NJ. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2013;45:25–33. - PMC - PubMed
    1. Stahl EA Wegmann D Trynka G Gutierrez-Achury J Do R Voight BF Kraft P Chen R Kallberg HJ Kurreeman FA , Diabetes Genetics Replication and Meta-analysis Consortium; Myocardial Infarction Genetics Consortium, Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 2012;44:483–489. - PMC - PubMed
    1. Goldstein BA Knowles JW Salfati E Ioannidis JP Assimes TL. Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Front Genet 2014;5:254. - PMC - PubMed
    1. Mega JL Stitziel NO Smith JG Chasman DI Caulfield MJ Devlin JJ Nordio F Hyde CL Cannon CP Sacks FM Poulter NR Sever PS Ridker PM Braunwald E Melander O Kathiresan S Sabatine MS. Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet 2015;385:2264–2271. - PMC - PubMed