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Review
. 2016 Dec 8;17(12):2059.
doi: 10.3390/ijms17122059.

Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases

Youn Kyung Houh  1 , Kyung Eun Kim  2 , Hyun Jeong Park  3 , Daeho Cho  4   5
Affiliations
Review

Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases

Youn Kyung Houh et al. Int J Mol Sci. .

Abstract

Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

Keywords: Erdr1; IL-18; cutaneous inflammation; melanoma; psoriasis; rosacea.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Erdr1 inhibits melanoma progression. Erdr1 suppresses metastasis by downregulating migration and invasion ability via HSP90 inhibition. In addition, Erdr1 reduces the apoptosis-regulating STAT3 signaling pathway. Erdr1 exerts its anti-cancerous effects by regulating HSP90 and STAT3 in melanoma.
Figure 2
Figure 2
Erdr1 is a potential therapeutic molecule for psoriasis due to its role in suppressing inflammation. Genetic and environmental triggers stimulate the epidermis, which produces chemokines for inflammatory immune cell infiltration. More specifically, Erdr1 inhibits the infiltration of CCR6+ Th17 cells via blockade of CCL20.
Figure 3
Figure 3
Erdr1 is suggested as a candidate target for rosacea treatment due to its anti-inflammatory and anti-angiogenic effects.
See this image and copyright information in PMC

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