Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec 9;17(12):2072.
doi: 10.3390/ijms17122072.

Nutrimetabolomics: An Update on Analytical Approaches to Investigate the Role of Plant-Based Foods and Their Bioactive Compounds in Non-Communicable Chronic Diseases

Oscar Daniel Rangel-Huerta  1 , Angel Gil  2   3
Affiliations
Review

Nutrimetabolomics: An Update on Analytical Approaches to Investigate the Role of Plant-Based Foods and Their Bioactive Compounds in Non-Communicable Chronic Diseases

Oscar Daniel Rangel-Huerta et al. Int J Mol Sci. .

Abstract

Metabolomics is the study of low-weight molecules present in biological samples such as biofluids, tissue/cellular extracts, and culture media. Metabolomics research is increasing, and at the moment, it has several applications in the food science and nutrition fields. In the present review, we provide an update about the most frequently used methodologies and metabolomic platforms in these areas. Also, we discuss different metabolomic strategies regarding the discovery of new bioactive compounds (BACs) in plant-based foods. Furthermore, we review the existing literature related to the use of metabolomics to investigate the potential protective role of BACs in the prevention and treatment of non-communicable chronic diseases, namely cardiovascular disease, diabetes, and cancer.

Keywords: bioactive compounds; metabolomics; non-communicable chronic diseases; nutrimetabolomics; plant-based food.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. World Health Organization . Noncommunicable Diseases Progress Monitor 2015. WHO Press; Geneva, Switzerland: 2015.
    1. Rangel-Huerta O.D., Pastor-Villaescusa B., Aguilera C.M., Gil A. A systematic review of the efficacy of bioactive compounds in cardiovascular disease: Phenolic compounds. Nutrients. 2015;7:5177–5216. doi: 10.3390/nu7075177. - DOI - PMC - PubMed
    1. Kitts D.D. Bioactive substances in food: Identification and potential uses. Can. J. Physiol. Pharmacol. 1994;72:423–434. doi: 10.1139/y94-062. - DOI - PubMed
    1. Gao X., Wang W., Wei S., Li W. Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds. China J. Chin. Mater. Med. 2009;34:2695–2700. - PubMed
    1. Kris-Etherton P.M., Hecker K.D., Bonanome A., Coval S.M., Binkoski A.E., Hilpert K.F., Griel A.E., Etherton T.D. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002;113:71–88. doi: 10.1016/S0002-9343(01)00995-0. - DOI - PubMed

MeSH terms

LinkOut - more resources