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Clinical Trial
. 2016 Dec 12:6:38774.
doi: 10.1038/srep38774.

A Novel Method for Estimating Myocardial Strain: Assessment of Deformation Tracking Against Reference Magnetic Resonance Methods in Healthy Volunteers

Kenneth Mangion  1   2 , Hao Gao  3 , Christie McComb  1   4 , David Carrick  2 , Guillaume Clerfond  1 , Xiaodong Zhong  5 , Xiaoyu Luo  3 , Caroline E Haig  6 , Colin Berry  1   2
Affiliations
Clinical Trial

A Novel Method for Estimating Myocardial Strain: Assessment of Deformation Tracking Against Reference Magnetic Resonance Methods in Healthy Volunteers

Kenneth Mangion et al. Sci Rep. .

Abstract

We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 81 healthy adults (44.6 ± 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1.5 T including cine, DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into 6 segments, and global and segmental peak circumferential strain were derived and analysed by age and sex. Peak circumferential strain differed between the 3 groups (DENSE: -19.4 ± 4.8%; deformation-tracking: -16.8 ± 2.4%; feature-tracking: -28.7 ± 4.8%) (ANOVA with Tukey post-hoc, F-value 279.93, p < 0.01). DENSE and deformation-tracking had better reproducibility than feature-tracking. Intra-class correlation co-efficient was >0.90. Larger magnitudes of strain were detected in women using deformation-tracking and DENSE, but not feature-tracking. Compared with a reference method (DENSE), deformation-tracking using cine imaging has similar diagnostic performance for circumferential strain assessment in healthy individuals. Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking.

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Conflict of interest statement

X.Z. is an employee of Siemens. The University of Glasgow holds a research agreement with Siemens Healthcare, who provided the DENSE work-in-progress CMR sequence and data analysis software. The other authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Peak circumferential strain assessed in 81 healthy volunteers using deformation-tracking, feature tracking and DENSE.
Outliers are depicted by circles.
Figure 2
Figure 2. Cine-strain estimation with in-house developed tissue deformation-tracking software.
Schematic illustration of deforming a target image to a reference image using a b-spline deformable registration method. Myocardial strain is calculated from the estimated deformation fields. The similarity measurement is defined as the sum of squared differences in pixel intensity between the two images, the deformation transformation between the target and the reference images is modeled with uniform cubic b-splines.
See this image and copyright information in PMC

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