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. 2016 Oct;2(4):352-362.
doi: 10.18001/TRS.2.4.7.

Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes

Andrew A Strasser  1 , Valentina Souprountchouk  1 , Amanda Kaufmann  1 , Sonja Blazekovic  1 , Frank Leone  2 , Neal L Benowitz  3 , Robert A Schnoll  1
Affiliations

Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes

Andrew A Strasser et al. Tob Regul Sci. 2016 Oct.

Abstract

Objectives: Little is known about the degree of nicotine replacement across first-generation e-cigarette brands, how e-cigarettes are used, and if there is variation across brands in relevant smoking phenotypes. The objective of this project was to collect data that are critical to better understanding, use, and exposure when using e-cigarettes, which may then inform clinical trials and tobacco regulatory policy.

Methods: Twenty-eight cigarette smokers were randomized to use one of 5 popular brands of e-cigarettes for a 10-day study. Day 1 (own cigarette brand) data established baseline levels for cotinine, carbon monoxide (CO), topography, cigarette liking, withdrawal, and craving. Participants returned on Days 5 and 10 to reassess these measures while exclusively using e-cigarettes.

Results: Compared to cigarette smoking, e-cigarettes provided significantly lower nicotine levels (25%-50%), reduced CO exposure, and lower ratings of liking (p < .05). Topography significantly differed between cigarette and e-cigarette sessions (p < .05). All brands significantly reduced withdrawal and craving (p < .05). There were no significant brand differences in outcome measures associated with exposure or use.

Conclusions: E-cigarettes are not liked as much as cigarettes, provide significantly lower nicotine replacement, reduce CO exposure, and mitigate withdrawal and craving. The patterns of use significantly differ compared to cigarette smoking.

Keywords: cotinine; e-cigarette; nicotine craving; nicotine withdrawal; smoking behavior; vaping.

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References

    1. US Centers for Disease Control and Prevention (CDC) Tobacco product use among adults – United States, 2012-2013. MMWR Morb Mortal Wkly Rep. 2014;63(25):542–547. - PMC - PubMed
    1. US Centers for Disease Control and Prevention (CDC) Current cigarette smoking among adults – United States, 2005-2012. MMWR Morb Mortal Wkly Rep. 2014;63(2):29–34. - PMC - PubMed
    1. Fiore MC, Jaen CR, Baker TB, et al. Treating tobacco use and dependence: 2008 update US Public Health Service clinical practice guideline executive summary. Respir Care. 2008;53:1217–1222. - PubMed
    1. Stead L, Lancaster T. Combined pharmacotherapy and behavioural intentions for smoking cessation. Cochrane Database Syst Rev. 2012;10:CD008286. - PubMed
    1. Yingst JM, Veldheer S, Hrabovsky S, et al. Factors associated with electronic cigarette users’ device preferences and transition from first generation to advanced generation devices. Nicotine Tob Res. 2015;17:1242–1246. - PMC - PubMed

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