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Review
. 2016 Dec;1386(1):45-68.
doi: 10.1111/nyas.13299.

Disease drivers of aging

Richard J Hodes  1 , Felipe Sierra  1 , Steven N Austad  2 , Elissa Epel  3 , Gretchen N Neigh  4 , Kristine M Erlandson  5 , Marissa J Schafer  6 , Nathan K LeBrasseur  6 , Christopher Wiley  7 , Judith Campisi  7 , Mary E Sehl  8 , Rosario Scalia  9 , Satoru Eguchi  9 , Balakuntalam S Kasinath  10 , Jeffrey B Halter  11 , Harvey Jay Cohen  12 , Wendy Demark-Wahnefried  13 , Tim A Ahles  14 , Nir Barzilai  15 , Arti Hurria  16 , Peter W Hunt  17
Affiliations
Review

Disease drivers of aging

Richard J Hodes et al. Ann N Y Acad Sci. 2016 Dec.

Abstract

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

Keywords: HIV; age-related; aging; cancer; chronic; diabetes; disease; pathology; prevention.

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Conflict of interest statement

Conflicts of interest

The authors declare no conflicts of interest

Figures

Figure 1
Figure 1
The pillars of geroscience. Adapted from Refs. and .
Figure 2
Figure 2
Model for age-related hyperglycemia. Reprinted from Ref.
Figure 3
Figure 3
Inflammation/coagulation in cancer and aging.
Figure 4
Figure 4
Kilogram change in fat (dashed line) and lean (solid line) body mass among 36 breast cancer patients receiving adjuvant chemotherapy. Adapted from Ref.
See this image and copyright information in PMC

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