doi: 10.1016/0165-1838(89)90126-4.
Effects of 5-hydroxytryptamine on rapidly adapting pulmonary stretch receptor activity in the rabbit
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- PMID: 2794342
- DOI: 10.1016/0165-1838(89)90126-4
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Effects of 5-hydroxytryptamine on rapidly adapting pulmonary stretch receptor activity in the rabbit
J Auton Nerv Syst.
1989 Jun.
Abstract
In anesthetized rabbits, intravenous administration of 5-hydroxytryptamine (5-HT, 10, 20, 40 and 80 micrograms/kg) led to an increase of rapidly adapting pulmonary stretch receptor activity. The magnitude of the increase was dose-dependent. The excitatory responses to any doses of 5-HT were not inhibited by prior treatment with isoprenaline (100-150 micrograms). The results indicate that the stimulation of rapidly adapting pulmonary stretch receptors by 5-HT is not caused by contraction of the airway smooth muscle.
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