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. 2017 Jan;23(1):77-81.
doi: 10.1111/hae.13048. Epub 2016 Dec 11.

Low dose prophylaxis in Tunisian children with haemophilia

E Gouider  1   2 , L Jouini  2 , M Achour  1   2 , H Elmahmoudi  2 , K Zahra  1   2 , W Saied  1   3 , B Meddeb  1   2
Affiliations

Low dose prophylaxis in Tunisian children with haemophilia

E Gouider et al. Haemophilia. 2017 Jan.

Abstract

Introduction: Low dose prophylaxis could be recommended in countries with limited resources.

Aim: We report our single centre experience in children with haemophilia.

Patients: Fifty-five children were included in our study with a weekly median dose of 30 UI kg-1 given once, twice or thrice a week. Age of initiation of prophylaxis is 5.32 years (0.64-11.44). Outcome assessment used were number of bleeding before and after initiating prophylaxis, haemophilia joint health score (HJHS), functional independence score in haemophilia (FISH) and quality of life with the Haemo-QoL.

Results: Reduction of number of bleeding was clear in all patients; HJHS, FISH and Haemo-QOL were satisfactory.

Conclusion: Low dose prophylaxis is effective and better than on-demand therapy. It should be the starting point for prophylaxis in countries with limited resources.

Keywords: functional independence score in haemophilia; haemophilia; haemophilia joint health score; low dose prophylaxis; prophylaxis.

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