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Case Reports
. 1989 Aug;52(8):1006-9.
doi: 10.1136/jnnp.52.8.1006.

Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology

E M Jones  1 , A Dawson
Affiliations
Case Reports

Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology

E M Jones et al. J Neurol Neurosurg Psychiatry. 1989 Aug.

Abstract

The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.

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Comment in

  • Pathology of neuroleptic malignant syndrome.
    Bakheit A, Behan WM. Bakheit A, et al. J Neurol Neurosurg Psychiatry. 1990 Mar;53(3):271. doi: 10.1136/jnnp.53.3.271. J Neurol Neurosurg Psychiatry. 1990. PMID: 2324764 Free PMC article. No abstract available.

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