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Case Reports
. 1978 Sep;2(4):502-5.
doi: 10.1097/00004728-197809000-00023.

Transient, severe periventricular hypodensity after leukemic prophylaxis with cranial irradiation and intrathecal methotrexate

L R Wendling, W A Bleyer, G Di Chiro, S K McIlvanie
Case Reports

Transient, severe periventricular hypodensity after leukemic prophylaxis with cranial irradiation and intrathecal methotrexate

L R Wendling et al. J Comput Assist Tomogr. 1978 Sep.

Abstract

Serial computed tomography (CT) demonstrated complete resolution of severe periventricular hypodensity occurring in a child after receiving prophylaxis for acute lymphocytic leukemia. The resolution of this encephalopathy suggests that early changes of subacute necrotizing leukoencephalopathy are reversible and CT is copable of detecting these early changes.

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