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Comment
. 2017 Jan;42(1):2-4.
doi: 10.1016/j.tibs.2016.11.005. Epub 2016 Dec 7.

Liquid Phase Transition in the Postsynaptic Density?

Mary B Kennedy  1 , Tara L Mastro  2
Affiliations
Comment

Liquid Phase Transition in the Postsynaptic Density?

Mary B Kennedy et al. Trends Biochem Sci. 2017 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Scaled Domain Diagrams of SynGAP and PSD-95. The domains surrounded by solid lines are contained in the fragments synGAP-CC-PBM and PSD-95-PSG that form the ordered 3:2 complex as described in the text. The domains surrounded by dashed lines are not included in the fragments. The C2 and RasGAP domains of synGAP mediate its GTPase-activating activity toward Rap (C2 plus RasGAP) and Ras (RasGAP alone) [12]. The disordered domain of synGAP contains several phosphorylation sites that regulate the specificity of the GAP domain and the affinity of synGAP for the PDZ domains of PSD-95 [7,11,13]. Abbreviations: CC, coiled-coil domain; GUK, guanylate kinase homology domain; PBM, PDZ domain binding motif; PDZ domain, named from PSD-95, Discs large, and ZO-1; PH, pleckstrin homology domain; PSD-95, postsynaptic density 95 kDa; PSG, PDS/SHG3/GUK domains; RasGAP, Ras-like GTPase-activating protein domain; SH3, Src homology 3 domain; SynGAP, synaptic Ras GTPase activating protein 1.
See this image and copyright information in PMC

Comment on

References

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