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Review
. 2016 Nov 28;22(44):9694-9705.
doi: 10.3748/wjg.v22.i44.9694.

Epidemiology of pancreatic cancer

Milena Ilic  1 , Irena Ilic  1
Affiliations
Review

Epidemiology of pancreatic cancer

Milena Ilic et al. World J Gastroenterol. .

Abstract

Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11th most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6% (ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease.

Keywords: Epidemiology; Incidence; Mortality; Pancreatic cancer; Risk factors; Trend.

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Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest.

Figures

Figure 1
Figure 1
Pancreatic cancer incidence and mortality in men and women, by regions, GLOBOCAN 2012 estimates.
Figure 2
Figure 2
Pancreatic cancer incidence in men (A) and women (B), GLOBOCAN 2012 estimates. 1Country with the lowest mortality rates; 2Country with the highest mortality rates. GLOBOCAN 2012 estimates[1].
Figure 3
Figure 3
Pancreatic cancer mortality in men (A) and women (B), GLOBOCAN 2012 estimates. 1Country with the lowest mortality rates; 2Country with the highest mortality rates. GLOBOCAN 2012 estimates[1].
Figure 4
Figure 4
Pancreatic cancer mortality trends among men (A) and women (B) in selected countries. GLOBOCAN 2012 estimates[1].
See this image and copyright information in PMC

References

    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer; 2013. Accessed 2016-03-04. Available from: http://globocan.iarc.fr.
    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–E386. - PubMed
    1. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. Bethesda, MD, 2016. Available from: http://seer.cancer.gov/csr/1975_2013/
    1. Hidalgo M, Cascinu S, Kleeff J, Labianca R, Löhr JM, Neoptolemos J, Real FX, Van Laethem JL, Heinemann V. Addressing the challenges of pancreatic cancer: future directions for improving outcomes. Pancreatology. 2013;15:8–18. - PubMed
    1. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet. 2011;378:607–620. - PMC - PubMed