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Review
. 2016:2016:7891574.
doi: 10.1155/2016/7891574. Epub 2016 Nov 10.

Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

Zhanpeng Wang  1 , Zhuonan Li  2 , Yanshuo Ye  1 , Lijuan Xie  3 , Wei Li  1
Affiliations
Review

Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

Zhanpeng Wang et al. Oxid Med Cell Longev. 2016.

Abstract

Accumulating evidence has indicated that oxidative stress (OS) is associated with the development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely unknown. Normally, OS occurs when the body receives any danger signal-from either an internal or external source-and further induces DNA oxidative damage and abnormal protein expression, placing the body into a state of vulnerability to the development of various diseases such as cancer. There are many factors involved in liver carcinogenesis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and nonalcoholic fatty liver disease (NAFLD). The relationship between OS and HCC has recently been attracting increasing attention. Therefore, elucidation of the impact of OS on the development of liver carcinogenesis is very important for the prevention and treatment of liver cancer. This review focuses mainly on the relationship between OS and the development of HCC from the perspective of cellular and molecular mechanisms and the etiology and therapeutic targets of HCC.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Mechanisms of oxidative stress on the regulation of liver cells.
Figure 2
Figure 2
The mechanisms of oxidative stress on HBV-, HCV-, and NASH-related HCC.
Figure 3
Figure 3
The mechanisms of OS-related HCC.
See this image and copyright information in PMC

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