Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan 3;89(1):102-123.
doi: 10.1021/acs.analchem.6b04630. Epub 2016 Dec 13.

Point-of-Care Diagnostics: Recent Developments in a Connected Age

Samiksha Nayak  1 , Nicole R Blumenfeld  1 , Tassaneewan Laksanasopin  2 , Samuel K Sia  1
Affiliations
Review

Point-of-Care Diagnostics: Recent Developments in a Connected Age

Samiksha Nayak et al. Anal Chem. .

Abstract

PubMed Disclaimer

Figures

Figure 1
Figure 1. The POC ecosystem in a connected age
POC devices require an integration of chemistry, fluidics, hardware and software. Traditional focus areas on POC development have been assay chemistry and microfluidics, but rapid progress is taking place in other technological and non-technological components which need to be considered by researchers in POC diagnostic devices.
Figure 2
Figure 2. POC use cases, uncoupling cost from infrastructure
Differences in budget and infrastructure level play a role in categorizing four distinct use cases for POC devices. Each setting imposes specific constraints on the design of POC devices.
Figure 3
Figure 3. Representative POC diagnostic devices
Examples of POC technology from industry and academia that feature integrated device designs that align with Use Cases 1 to 4: (1) RAPIDPoint® 500 Blood Gas System from the company Siemens, Photo courtesy of Siemens Healthineers. ©2016 Siemens Healthcare Diagnostics Inc. Used with permission. (2) BioStampRC® system from the company MC10, Copyright 2016 MC10, Inc. Used with permission; (3) GeneXpert system (four-module configuration) from the company Cepheid, Photo courtesy of Cepheid Inc.; (4) VPAD technology (electronics-enabled paper-based diagnostic test & sliding strip nucleic-acid testing device) from the company Diagnostics For All and the mChip smartphone dongle system from our lab. Reprinted from Biosensors and Bioelectronics, Vol. 78, Lee, S.; Aranyosi, A.; Wong, M. D.; Hong, J. H.; Lowe, J.; Chan, C.; Garlock, D.; Shaw, S.; Beattie, P. D.; Kratochvil, Z., Flexible opto-electronics enabled microfluidics systems with cloud connectivity for point-of-care micronutrient analysis, pp. 290-299 (ref), Copyright 2016, with permission from Elsevier. Reproduced from Connelly, J. T.; Rolland, J. P.; Whitesides, G. M. Anal Chem 2015, 87, 7595-7601. (ref) Copyright 2015 American Chemical Society. From Laksanasopin, T.; Guo, T. W.; Nayak, S.; Sridhara, A. A.; Xie, S.; Olowookere, O. O.; Cadinu, P.; Meng, F.; Chee, N. H.; Kim, J. Science translational medicine 2015, 7, 273re271-273re271. (ref) Reprinted with permission from AAAS.
See this image and copyright information in PMC

References

    1. Christiansen, C.; Grossman, J. H.; Hwang, J.; New York: McGraw-Hill, 2008.

    1. Sia SK, Kricka LJ. Lab on a Chip. 2008;8:1982–1983. - PubMed
    1. Chin CD, Linder V, Sia SK. Lab on a Chip. 2012;12:2118–2134. - PubMed
    1. Slomovic S, Pardee K, Collins JJ. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:14429–14435. - PMC - PubMed
    1. Groff K, Brown J, Clippinger AJ. Biotechnology advances. 2015;33:1787–1798. - PubMed

Publication types