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Review
. 2017 Jan 6:57:329-348.
doi: 10.1146/annurev-pharmtox-010716-105055. Epub 2016 Dec 7.

Will There Be a Cure for Ebola?

Anthony P Cardile  1 , Travis K Warren  1 , Karen A Martins  1 , Ronald B Reisler  1 , Sina Bavari  1
Affiliations
Review

Will There Be a Cure for Ebola?

Anthony P Cardile et al. Annu Rev Pharmacol Toxicol. .

Abstract

Despite the unprecedented Ebola virus outbreak response in West Africa, no Ebola medical countermeasures have been approved by the US Food and Drug Administration. However, multiple valuable lessons have been learned about the conduct of clinical research in a resource-poor, high risk-pathogen setting. Numerous therapeutics were explored or developed during the outbreak, including repurposed drugs, nucleoside and nucleotide analogues (BCX4430, brincidofovir, favipiravir, and GS-5734), nucleic acid-based drugs (TKM-Ebola and AVI-7537), and immunotherapeutics (convalescent plasma and ZMapp). We review Ebola therapeutics progress in the aftermath of the West Africa Ebola virus outbreak and attempt to offer a glimpse of a path forward.

Keywords: BCX4430; GS-5734; ZMapp; brincidofovir; convalescent plasma; favipiravir.

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