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Comment
. 2016 Nov 10;375(19):1898-1899.
doi: 10.1056/NEJMc1611699.

Innate Immunity and Asthma Risk

Justyna Gozdz  1 , Carole Ober  2 , Donata Vercelli  3
Affiliations
Comment

Innate Immunity and Asthma Risk

Justyna Gozdz et al. N Engl J Med. .
No abstract available

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Conflict of interest statement

Since publication of their article, the authors report no further potential conflict of interest.

Figures

Figure 1
Figure 1. Protection against Allergen-Induced Experimental Asthma by Dust from Amish and Hutterite Barns
Amish or Hutterite aqueous barn-dust extracts (5 mg of dust equivalent in 50 μl per treatment for a total of 14 treatments) were instilled intranasally every other day from day –10 to day 21 into adult (6-to-7-week-old) BALB/c mice that received house-dust mite extract (HDM) (Greer, 100 μg) intranasally on days 0, 7, 14, and 21. Airway resistance (shown as centimeters of water per milliliter per second and stimulated in response to increasing doses of acetylcholine administered intravenously) (Panel A) and bronchoalveolar-lavage cellularity (Panel B) were measured on day 22, as described in our article. Hutterite barn-dust extracts were prepared as described in our article. The results are for two experiments involving six to nine mice per group. Statistical differences in experimental measures were assessed with the use of a mixed-effects model for repeated measures (Panel A) and Student’s t-test (Panel B). I bars represent the standard error. PBS denotes phosphate-buffered saline.
See this image and copyright information in PMC

Comment on

  • Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
    Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Stein MM, et al. N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749. N Engl J Med. 2016. PMID: 27518660 Free PMC article.
  • Innate Immunity and Asthma Risk.
    Cooper DJ. Cooper DJ. N Engl J Med. 2016 Nov 10;375(19):1897. doi: 10.1056/NEJMc1611699. N Engl J Med. 2016. PMID: 27959652 No abstract available.
  • Innate Immunity and Asthma Risk.
    George M. George M. N Engl J Med. 2016 Nov 10;375(19):1897. doi: 10.1056/NEJMc1611699. N Engl J Med. 2016. PMID: 28112884 No abstract available.
  • Innate Immunity and Asthma Risk.
    Nadelman I. Nadelman I. N Engl J Med. 2016 Nov 10;375(19):1897-1898. doi: 10.1056/NEJMc1611699. N Engl J Med. 2016. PMID: 28112885 No abstract available.

References

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    1. Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364:701–9. - PubMed
    1. Wlasiuk G, Vercelli D. The farm effect, or: when, what and how a farming environment protects from asthma and allergic disease. Curr Opin Allergy Clin Immunol. 2012;12:461–6. - PubMed