The Vascular Impairment of Cognition Classification Consensus Study

doi:10.1016/j.jalz.2016.10.007

. 2017 Jun;13(6):624-633.

doi: 10.1016/j.jalz.2016.10.007. Epub 2016 Dec 10.

The Vascular Impairment of Cognition Classification Consensus Study

Olivia A Skrobot¹, John O'Brien², Sandra Black³, Christopher Chen⁴, Charles DeCarli⁵, Timo Erkinjuntti⁶, Gary A Ford⁷, Rajesh N Kalaria⁸, Leonardo Pantoni⁹, Florence Pasquier¹⁰, Gustavo C Roman¹¹, Anders Wallin¹², Perminder Sachdev¹³, Ingmar Skoog¹⁴; VICCCS group; Yoav Ben-Shlomo¹⁵, Anthony P Passmore¹⁶, Seth Love¹, Patrick G Kehoe¹⁷

Collaborators, Affiliations

Collaborators

VICCCS group:
F E Taragano, J Kril, M Cavalieri, K A Jellinger, G G Kovacs, S Engelborghs, C Lafosse, P H Bertolucci, S Brucki, P Caramelli, T C de Toledo Ferraz Alves, C Bocti, T Fulop, D B Hogan, G R Hsiung, A Kirk, L Leach, A Robillard, D J Sahlas, Q Guo, J Tian, L Hokkanen, H Jokinen, S Benisty, V Deramecourt, J Hauw, H Lenoir, M Tsatali, M Tsolaki, U Sundar, R F Coen, A D Korczyn, M Altieri, M Baldereschi, C Caltagirone, G Caravaglios, A Di Carlo, V DI Piero, G Gainotti, S Galluzzi, G Logroscino, P Mecocci, D V Moretti, A Padovani, T Fukui, M Ihara, T Mizuno, S Y Kim, R Akinyemi, O Baiyewu, A Ogunniyi, A Szczudlik, A J Bastos-Leite, H Firmino, J Massano, A Verdelho, L S Kruglov, M K Ikram, N Kandiah, E Arana, J Barroso-Ribal, T Calatayud, A J Cruz-Jentoft, S López-Pousa, P Martinez-Lage, M Mataro, A Börjesson-Hanson, E Englund, E J Laukka, C Qiu, M Viitanen, G J Biessels, F-E de Leeuw, T den Heijer, L G Exalto, L J Kappelle, N D Prins, E Richard, B Schmand, E van den Berg, W M van der Flier, B Bilgic, L M Allan, J Archer, J Attems, A Bayer, D Blackburn, C Brayne, R Bullock, P J Connelly, A Farrant, M Fish, K Harkness, P G Ince, P Langhorne, J Mann, F E Matthews, P Mayer, S T Pendlebury, R Perneczky, R Peters, D Smithard, B C Stephan, J E Swartz, S Todd, D J Werring, S N Wijayasiri, G Wilcock, G Zamboni, R Au, S Borson, A Bozoki, J N Browndyke, M M Corrada, P K Crane, B S Diniz, L Etcher, H Fillit, S M Greenberg, L T Grinberg, S W Hurt, M Lamar, M Mielke, B R Ott, G Perry, W J Powers, C Ramos-Estebanez, B Reed, R O Roberts, J R Romero, A J Saykin, S Seshadri, L Silbert, Y Stern, C Zarow

Affiliations

¹ Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK.
² Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.
³ Sunnybrook Research Institute, University of Toronto, Canada.
⁴ Department of Pharmacology, Memory Aging and Cognition Centre, National University of Singapore, Singapore.
⁵ Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA.
⁶ Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, HUS, Finland.
⁷ Divison of Medical Sciences, Oxford University, Oxford, UK.
⁸ Institute of Neuroscience, Newcastle upon Tyne, UK.
⁹ Department of Neuroscience, University of Florence, Area Drug and Child Health (NEUROFARBA), Florence, Italy.
¹⁰ Université Lille, Inserm, CHU Lille, U1171, Degenerative and vascular cognitive disorders, Lille, France.
¹¹ Methodist Neurological Institute, Houston, TX, USA.
¹² Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Memory Clinic at Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden.
¹³ School of Psychiatry, University of New South Wales, Sydney, Australia; CHeBA (Centre for Healthy Brain Ageing), Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
¹⁴ Center for Health and Ageing (AGECAP), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
¹⁵ School of Social and Community Medicine, University of Bristol, Bristol, UK.
¹⁶ Institute of Clinical Sciences, Queens University Belfast, Royal Victoria Hospital, Belfast, UK.
¹⁷ Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Electronic address: patrick.kehoe@bristol.ac.uk.

PMID: 27960092
DOI: 10.1016/j.jalz.2016.10.007

Free article

The Vascular Impairment of Cognition Classification Consensus Study

Olivia A Skrobot et al. Alzheimers Dement. 2017 Jun.

Free article

. 2017 Jun;13(6):624-633.

doi: 10.1016/j.jalz.2016.10.007. Epub 2016 Dec 10.

Authors

Collaborators

VICCCS group:
F E Taragano, J Kril, M Cavalieri, K A Jellinger, G G Kovacs, S Engelborghs, C Lafosse, P H Bertolucci, S Brucki, P Caramelli, T C de Toledo Ferraz Alves, C Bocti, T Fulop, D B Hogan, G R Hsiung, A Kirk, L Leach, A Robillard, D J Sahlas, Q Guo, J Tian, L Hokkanen, H Jokinen, S Benisty, V Deramecourt, J Hauw, H Lenoir, M Tsatali, M Tsolaki, U Sundar, R F Coen, A D Korczyn, M Altieri, M Baldereschi, C Caltagirone, G Caravaglios, A Di Carlo, V DI Piero, G Gainotti, S Galluzzi, G Logroscino, P Mecocci, D V Moretti, A Padovani, T Fukui, M Ihara, T Mizuno, S Y Kim, R Akinyemi, O Baiyewu, A Ogunniyi, A Szczudlik, A J Bastos-Leite, H Firmino, J Massano, A Verdelho, L S Kruglov, M K Ikram, N Kandiah, E Arana, J Barroso-Ribal, T Calatayud, A J Cruz-Jentoft, S López-Pousa, P Martinez-Lage, M Mataro, A Börjesson-Hanson, E Englund, E J Laukka, C Qiu, M Viitanen, G J Biessels, F-E de Leeuw, T den Heijer, L G Exalto, L J Kappelle, N D Prins, E Richard, B Schmand, E van den Berg, W M van der Flier, B Bilgic, L M Allan, J Archer, J Attems, A Bayer, D Blackburn, C Brayne, R Bullock, P J Connelly, A Farrant, M Fish, K Harkness, P G Ince, P Langhorne, J Mann, F E Matthews, P Mayer, S T Pendlebury, R Perneczky, R Peters, D Smithard, B C Stephan, J E Swartz, S Todd, D J Werring, S N Wijayasiri, G Wilcock, G Zamboni, R Au, S Borson, A Bozoki, J N Browndyke, M M Corrada, P K Crane, B S Diniz, L Etcher, H Fillit, S M Greenberg, L T Grinberg, S W Hurt, M Lamar, M Mielke, B R Ott, G Perry, W J Powers, C Ramos-Estebanez, B Reed, R O Roberts, J R Romero, A J Saykin, S Seshadri, L Silbert, Y Stern, C Zarow

Affiliations

¹ Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK.
² Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.
³ Sunnybrook Research Institute, University of Toronto, Canada.
⁴ Department of Pharmacology, Memory Aging and Cognition Centre, National University of Singapore, Singapore.
⁵ Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA.
⁶ Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, HUS, Finland.
⁷ Divison of Medical Sciences, Oxford University, Oxford, UK.
⁸ Institute of Neuroscience, Newcastle upon Tyne, UK.
⁹ Department of Neuroscience, University of Florence, Area Drug and Child Health (NEUROFARBA), Florence, Italy.
¹⁰ Université Lille, Inserm, CHU Lille, U1171, Degenerative and vascular cognitive disorders, Lille, France.
¹¹ Methodist Neurological Institute, Houston, TX, USA.
¹² Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Memory Clinic at Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden.
¹³ School of Psychiatry, University of New South Wales, Sydney, Australia; CHeBA (Centre for Healthy Brain Ageing), Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia.
¹⁴ Center for Health and Ageing (AGECAP), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
¹⁵ School of Social and Community Medicine, University of Bristol, Bristol, UK.
¹⁶ Institute of Clinical Sciences, Queens University Belfast, Royal Victoria Hospital, Belfast, UK.
¹⁷ Dementia Research Group, Faculty of Health Sciences, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Electronic address: patrick.kehoe@bristol.ac.uk.

PMID: 27960092
DOI: 10.1016/j.jalz.2016.10.007

Abstract

Introduction: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment.

Methods: The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines.

Results: VICCCS had a mean of 122 (98-153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge.

Discussion: VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research.

Keywords: Consensus; Criteria; Delphi; Guidelines; Vascular cognitive impairment; Vascular dementia.

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The Vascular Impairment of Cognition Classification Consensus Study

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The Vascular Impairment of Cognition Classification Consensus Study

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