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Review
. 2017 Jul:206:45-51.
doi: 10.1016/j.vetmic.2016.11.029. Epub 2016 Dec 2.

Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses

Volker Gerdts  1 , Alexander Zakhartchouk  2
Affiliations
Review

Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses

Volker Gerdts et al. Vet Microbiol. 2017 Jul.

Abstract

The recent introduction of the porcine epidemic diarrhea virus (PEDV) into the North American swine herd has highlighted again the need for effective vaccines for swine coronaviruses. While vaccines for transmissible gastroenteritis virus (TGEV) have been available to producers around the world for a long time, effective vaccines for PEDV and deltacoronaviruses were only recently developed or are still in development. Here, we review existing vaccine technologies for swine coronaviruses and highlight promising technologies which may help to control these important viruses in the future.

Keywords: Coronaviruses; Pigs; Review; Vaccines.

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Figures

Fig. 1
Fig. 1
Genome organization of swine enteric coronaviruses TGEV, PEDV, and PDCoV. Genes for structural proteins are presented in yellow. Putative accessory genes are shown in green. Nonstructural proteins encoded by ORF1a/b are presented in blue. TGEV, transmissible gastroenteritis coronavirus; PEDV, porcine epidemic diarrhea virus; PDCoV, porcine deltacoronavirus; S, spike; E, envelope; M, membrane; N, nucleocapsid. Genomes have 5′ cap and 3′ poly A tail.
See this image and copyright information in PMC

References

    1. Bae J.L., Lee J.G., Kang T.J., Jang H.S., Jang Y.S., Yang M.S. Induction of antigen-specific systemic and mucosal immune responses by feeding animals transgenic plants expressing the antigen. Vaccine. 2003;21:4052–4058. - PubMed
    1. Baek P.S., Choi H.W., Lee S., Yoon I.J., Lee Y.J., Lee du S., Lee C. Efficacy of an inactivated genotype 2b porcine epidemic diarrhea virus vaccine in neonatal piglets. Vet. Immunol. Immunopathol. 2016;174:45–49. - PMC - PubMed
    1. Bandrick M., Ariza-Nieto C., Baidoo S.K., Molitor T.W. Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets. Dev. Comp. Immunol. 2014;43:114–120. - PMC - PubMed
    1. Belouzard S., Millet J.K., Licitra B.N., Whittaker G.R. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses. 2012;4:1011–1033. - PMC - PubMed
    1. Berube N., Hauta Shirley, Popowych Yurij, Connor Wayne, Erickson Jan, Tetland Sherry, Bock Ken, Allan Brenda, van den Hurk Jan, Makadiya Niraj, van Moorlehem Elaine, Brownlie Robert, Zakhartchouk Alexander, Rawlyk Neil, Walker Stew, Wheler Colette, Don Wilson S.K., Tikoo, Yan Zhou, Andrew Potter A., Volker Gerdts . North American PRRS Symposium; Chicago: 2015. Development of a Novel Vaccine for Porcine Epidemic Diarrhea Virus.

MeSH terms