TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Maria Henström¹, Fatemeh Hadizadeh^{1

2}, Arthur Beyder³, Ferdinando Bonfiglio^{1

4}, Tenghao Zheng¹, Ghazaleh Assadi¹, Joseph Rafter¹, Luis Bujanda⁴, Lars Agreus⁵, Anna Andreasson^{5

6}, Aldona Dlugosz⁷, Greger Lindberg⁷, Peter T Schmidt⁷, Pontus Karling⁸, Bodil Ohlsson⁹, Nicholas J Talley¹⁰, Magnus Simren¹¹, Susanna Walter¹², Mira Wouters¹³, Gianrico Farrugia³, Mauro D'Amato^{4

14

15

16}

Affiliations

¹ Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
² School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Gastrointestinal and Liver Diseases, BioDonostia Health Research Institute, San Sebastian, Spain.
⁵ Division for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
⁶ Stress Research Institute, Stockholm University, Stockholm, Sweden.
⁷ Department of Medicine, Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.
⁸ Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
⁹ Department of Internal Medicine, Lund University, Skåne University Hospital, Sweden.
¹⁰ Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
¹¹ Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹² Division of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
¹³ Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven University, Leuven, Belgium.
¹⁴ BioCruces Health Research Institute, Bilbao, Spain.
¹⁵ IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
¹⁶ Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

PMID: 27974553
PMCID: PMC5561393
DOI: 10.1136/gutjnl-2016-313346

Comment

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Maria Henström et al. Gut. 2017 Sep.

. 2017 Sep;66(9):1725-1727.

doi: 10.1136/gutjnl-2016-313346. Epub 2016 Dec 14.

Authors

Affiliations

¹ Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
² School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Gastrointestinal and Liver Diseases, BioDonostia Health Research Institute, San Sebastian, Spain.
⁵ Division for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
⁶ Stress Research Institute, Stockholm University, Stockholm, Sweden.
⁷ Department of Medicine, Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden.
⁸ Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
⁹ Department of Internal Medicine, Lund University, Skåne University Hospital, Sweden.
¹⁰ Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
¹¹ Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹² Division of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
¹³ Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven University, Leuven, Belgium.
¹⁴ BioCruces Health Research Institute, Bilbao, Spain.
¹⁵ IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
¹⁶ Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

PMID: 27974553
PMCID: PMC5561393
DOI: 10.1136/gutjnl-2016-313346

No abstract available

Keywords: CONSTIPATION; GENETICS; ION CHANNELS; IRRITABLE BOWEL SYNDROME; POLYMORPHIC VARIATION.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None.

Figures

**Figure 1**
Correlation between *TRPM8* genotype and average Bristol Stool Form Scale (BSFS) scores. Left: Spearman correlation statistics. Right: frequency of *TRPM8* alleles across BSFS quartile groups (alleles from each SNP are colour-coded as in the table on the left).

See this image and copyright information in PMC

Comment on

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency.
Jankipersadsing SA, Hadizadeh F, Bonder MJ, Tigchelaar EF, Deelen P, Fu J, Andreasson A, Agreus L, Walter S, Wijmenga C, Hysi P, D'Amato M, Zhernakova A. Jankipersadsing SA, et al. Gut. 2017 Apr;66(4):756-758. doi: 10.1136/gutjnl-2016-312398. Epub 2016 Jul 29. Gut. 2017. PMID: 27473416 Free PMC article. No abstract available.

References

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1. Beyder A, Mazzone A, Strege PR, et al. . Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome. Gastroenterology 2014;146:1659–68. 10.1053/j.gastro.2014.02.054 - DOI - PMC - PubMed
1. Ek WE, Reznichenko A, Ripke S, et al. . Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. Gut 2015;64:1774–82. 10.1136/gutjnl-2014-307997 - DOI - PubMed
1. Walter SA, Kjellström L, Nyhlin H, et al. . Assessment of normal bowel habits in the general adult population: the Popcol study. Scand J Gastroenterol 2010;45:556–66. 10.3109/00365520903551332 - DOI - PubMed
1. Blackshaw LA. Transient receptor potential cation channels in visceral sensory pathways. Br J Pharmacol 2014;171:2528–36. 10.1111/bph.12641 - DOI - PMC - PubMed

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TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Affiliations

TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M

Authors

Affiliations

Conflict of interest statement

Figures

Comment on

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

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Medical