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Editorial
. 2016 Dec 20;7(51):83833-83834.
doi: 10.18632/oncotarget.13805.

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

Victoria Cohen-Kaplan, Aaron Ciechanover, Ido Livneh
Editorial

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

Victoria Cohen-Kaplan et al. Oncotarget. .
No abstract available

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Figures

Figure 1
Figure 1. Role of p62 in shuttling ubiquitinated proteins to the proteasome and in stress-induced proteaphagy
I. Structure of p62. p62 recognizes ubiquitinated substrates via its UBA domain and the proteasome via PB1 domain. LIR denotes the LC3 binding domain. II. p62 targets ubiquitinated proteins to the 26S proteasome. III. p62-mediated stress-induced proteaphagy. Amino acid starvation stimulates ubiquitination of specific proteasomal subunits (a). leading to their recognition by the p62 UBA domain, and to subsequent binding – in a similar manner to other ubiquitinated targets – to LC3 (via the LIR domain) in the evolving phagophore (b). Following its maturation, the autophagosome fuses with a lysosome to generate an autophagolysosme (c). where proteasomes and other cargoes are degraded by hydrolases (d).
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References

    1. Cohen-Kaplan V, et al. Proc Natl Acad Sci. 2016. p. 201615455. - DOI - PubMed
    1. Youle RJ, Narendra DP, et al. Nat Rev Mol Cell Biol. 2011;12:9–14. doi: 10.1038/nrm3028. - DOI - PMC - PubMed
    1. Marshall RS, et al. Mol Cell. 2015;58:1053–66. doi: 10.1016/j.molcel.2015.04.023. - DOI - PMC - PubMed
    1. Waite KA, et al. J Biol Chem. 2015;291:3239–53. doi: 10.1074/jbc.M115.699124. - DOI - PMC - PubMed
    1. Seibenhener M, Babu J, et al. Mol Cell Biol. 2004;24:8055–68. doi: 10.1128/MCB.24.18.8055. - DOI - PMC - PubMed

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